In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular
activities in a spatially and temporally controlled manner. Numerous membraneless …

Biomolecular condensation is emerging as an essential process for cellular
compartmentalization. The formation of biomolecular condensates can be driven by liquid …

Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the
predominant clinical manifestation of spasticity in the lower extremities. HSP is categorised …

The dual-specificity kinase DYRK3 controls the formation and dissolution of multiple
biomolecular condensates, regulating processes including stress recovery and mitotic …

Type I collagen is the main component of bone matrix and other connective tissues.
Rerouting of its procollagen precursor to a degradative pathway is crucial for osteoblast …

Coat proteins play multiple roles in the life cycle of a membrane‐bound transport
intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an …

Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

Under stress, the endomembrane system undergoes reorganization to support
autophagosome biogenesis, which is a central step in autophagy. How the endomembrane …

Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes
within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from …