Antibody therapeutics are a large and rapidly expanding drug class providing major health
benefits. We provide a snapshot of current antibody therapeutics including their formats …

Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Introduction Undruggable targets refer to clinically meaningful therapeutic targets that are
'difficult to drug'or 'yet to be drugged'via traditional approaches. Featuring characteristics of …

The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …

Achieving the full potential of therapeutic proteins to access and target intracellular receptors
will have enormous benefits in advancing human health and fighting disease. Existing …

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E
trimer [FcB (L17E) 3] was designed for immunoglobulin G (IgG) delivery into cells. Particle …

The current therapeutic antibody market in the US consists of 100 antibody-based products
and their market value is expected to explode beyond $300 billion by 2025. These therapies …

Proteins are essential for life, as they participate in all vital processes in the body. In the past
decade, delivery of active proteins to specific cells and organs has attracted increasing …

Bacteria produce polycationic homopoly (amino acid) s, which are characterized by
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …

Nanocarriers that deliver functional proteins to cell interiors are an attractive platform for the
intracellular delivery of intact proteins without further modification, with in vivo compatibility …