[HTML][HTML] Recent major transcriptomics and epitranscriptomics contributions toward personalized and precision medicine

G Mubarak, FR Zahir - Journal of Personalized Medicine, 2022 - mdpi.com
With the advent of genome-wide screening methods—beginning with microarray
technologies and moving onto next generation sequencing methods—the era of precision …

Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke

AK Chokkalla, K Pajdzik, X Dou, Q Dai… - Translational Stroke …, 2023 - Springer
Methylation of adenosine at N1 position yields N 1-methyladenosine (m1A), which is an
epitranscriptomic modification that regulates mRNA metabolism. Recent studies showed that …

[HTML][HTML] Prognostic role of M6A-associated immune genes and cluster-related tumor microenvironment analysis: A multi-omics practice in stomach adenocarcinoma

N Luo, M Fu, Y Zhang, X Li, W Zhu, F Yang… - Frontiers in Cell and …, 2022 - frontiersin.org
N6-methylandrostenedione (m6A) methylation plays a very important role in the
development of malignant tumors. The immune system is the key point in the progression of …

Immunomodulatory role of glycoRNAs in the brain

AK Chokkalla, S Jeong… - Journal of Cerebral …, 2023 - journals.sagepub.com
Glycosylation of lipids and proteins significantly increases the molecular diversity in the
brain. Membrane-localized glycoconjugates facilitate critical neuro-immune interactions …

[HTML][HTML] Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection

H Li, J Lin, S Cheng, J Chi, J Luo, Y Tang… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Helicobacter pylori (H. pylori) infection is an important factor in the occurrence
of human gastric diseases, but its pathogenic mechanism is not clear. N6-methyladenosine …

PTPRG activates m6A methyltransferase VIRMA to block mitochondrial autophagy mediated neuronal death in Alzheimer's disease

J Luo, X Huang, R Li, J Xie, L Chen, C Zou, Z Pei… - medRxiv, 2022 - medrxiv.org
In Alzheimer's disease (AD), neuronal death is one of the key pathology. However, the
initiation of neuronal death in AD is far from clear, and new targets are urgently needed to …

[HTML][HTML] Altered N6-Methyladenosine Modification Patterns and Transcript Profiles Contributes to Cognitive Dysfunction in High-Fat Induced Diabetic Mice

Z Cao, Y An, Y Lu - International Journal of Molecular Sciences, 2024 - mdpi.com
N6-methyladenosine (m6A) constitutes the paramount post-transcriptional modification
within eukaryotic mRNA. This modification is subjected to stimulus-dependent regulation …

Insights into the Therapeutic Potential of Phytoconstituents as an Epigenetic Modulators in Diabetic Nephropathy

K Thapa, H Khan, AK Grewal, N Kanojia, G Kaur… - Current Pharmacology …, 2023 - Springer
Chronic diabetes is commonly associated with the development of nephropathy, which is a
prevalent complication. Hyperglycemia is believed to initiate various biochemical …

m6A modification and its role in neural development and neurological diseases

X Wan, Y Ge, S Xu, Y Feng, Y Zhu, L Yin, Y Pu… - …, 2023 - Taylor & Francis
N6-methyladenosine (m6A) methylation, the most prevalent post-transcriptional modification
in eukaryotes, represents a highly dynamic and reversible process that is regulated by m6A …

Constant light exposure in early life induces m6A-mediated inhibition of IGF gene family in the chicken

Y Yang, P Xu, J Liu, M Zhao, W Cong… - Journal of Animal …, 2022 - academic.oup.com
Insulin-like growth factor (IGF) family plays important roles in regulating the development of
various organ systems through stimulating cell proliferation and differentiation. Photoperiod …