FTO ameliorates learning and memory impairment by activating PI3K/AKT/mTOR signaling pathway in a neurodevelopmental model of schizophrenia

Y Zhong, L Zhang, Z Song, C Wei, K Zhang, H Liu… - 2024 - researchsquare.com
Background The pathogenesis of cognitive dysfunction in schizophrenia (SCZ) is still
unclear, and m6A methylation may be involved in the neuropsychiatric diseases. The aim of …

Development and Validation of a Novel Prognostic Model for Lower-Grade Glioma Based on the m6A-regulated Genes

Y Zhang, N Luo, X Li, W Zhu, M Fu, F Yang, Z Chen… - 2023 - researchsquare.com
Background: Methylation of N6-methylandenosine (m6A) has important roles in the growth
of tumors and cellular biological processes. The immune system is involved in …

The complex roles of m6A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative …

Y Li, J Xue, Y Ma, K Ye, X Zhao, F Ge, F Zheng… - Neural Regeneration … - journals.lww.com
Abstract N6-methyladenosine (m 6 A), the most prevalent and conserved RNA modification
in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA …

Implicación de la metilación de ácidos nucleicos en biología y evolución: desde los primeros homínidos hasta los humanos modernos: Revisión

G Dorado, F Luque, FJ Esteban, P Pascual… - …, 2022 - dialnet.unirioja.es
Los avances recientes en biología molecular, en general, y secuenciación de ácidos
nucleicos, en particular, han posibilitado descubrimientos fascinantes. Así, ahora se sabe …

Identification of potential natural compound inhibitors and drug like molecules against human METTL3 by docking and molecular dynamics simulation

S Manna, P Samal, R Basak, A Mitra, AK Roy, R Kundu… - bioRxiv, 2022 - biorxiv.org
Nucleotide level chemical modification in transcriptome is critical in regulating different
cellular processes, including cancer. The most investigated epitranscriptomic modification is …

[图书][B] Cell Type-Specific RNA Metabolism in the Drosophila Nervous System

M Aboukilila - 2021 - search.proquest.com
High-throughput technologies of functional genomics have revolutionized the dissection of
gene expression regulation during development & pathology. However, most of the …