The progress of fabrication designs of polymeric microneedles and related biomedical applications

X Jiang, W Zhang, R Terry, W Li - BMEMat, 2023 - Wiley Online Library
Microneedles (MNs) have been broadly used for transdermal delivery of a variety of drugs,
ranging from small chemicals to biological macromolecules, due to the properties of …

Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy

L Yang, D Zhang, W Li, H Lin, C Ding, Q Liu… - Nature …, 2023 - nature.com
The treatment of diabetic wounds faces enormous challenges due to complex wound
environments, such as infected biofilms, excessive inflammation, and impaired …

Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery

X Hou, J Li, Y Hong, H Ruan, M Long, N Feng, Y Zhang - Biomedicines, 2023 - mdpi.com
Transdermal drug delivery (TDD) is one of the key approaches for treating diseases,
avoiding first-pass effects, reducing systemic adverse drug reactions and improving patient …

Multifunctional silk fibroin methacryloyl microneedle for diabetic wound healing

G Guan, Q Zhang, Z Jiang, J Liu, J Wan, P Jin, Q Lv - Small, 2022 - Wiley Online Library
Diabetic wound is one of the common complications in diabetic patients, which exhibits
chronic, hard‐to‐heal characteristics. The healing process of wounds is impaired by several …

Separable microneedles with photosynthesis-driven oxygen manufactory for diabetic wound healing

E Zhao, T Xiao, Y Tan, X Zhou, Y Li… - … Applied Materials & …, 2023 - ACS Publications
Oxygen plays an important role in diabetic chronic wound healing by regulating various life
activities such as cell proliferation, migration, and angiogenesis. Therefore, oxygen …

Hyaluronic acid-based CuS nanoenzyme biodegradable microneedles for treating deep cutaneous fungal infection without drug resistance

B Wang, W Zhang, Q Pan, J Tao, S Li, T Jiang… - Nano …, 2023 - ACS Publications
Deep cutaneous fungal infection (DCFI) is difficult to be treated by the traditional topical
application due to low drug transdermal efficiency, poor fungicidal effect, and easy to …

Rapid induction of long-lasting systemic and mucosal immunity via Thermostable Microneedle-Mediated Chitosan Oligosaccharide-Encapsulated DNA Nanoparticles

M Li, L Yang, C Wang, M Cui, Z Wen, Z Liao, Z Han… - Acs Nano, 2023 - ACS Publications
Most existing vaccines, delivered by intramuscular injection (IM), are typically associated
with stringent storage requirements under cold-chain distribution and professional …

Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS 2

W Du, X Li, M Zhang, G Ling, P Zhang - Journal of Materials Chemistry …, 2023 - pubs.rsc.org
Microneedle (MN) systems for painless transdermal drug delivery have been well developed
over the past few years to overcome the problems of subcutaneous injections. Hyaluronic …

[HTML][HTML] pH-activatable oxidative stress amplifying dissolving microneedles for combined chemo-photodynamic therapy of melanoma

Y Huang, H Lai, J Jiang, X Xu, Z Zeng, L Ren… - Asian journal of …, 2022 - Elsevier
Photodynamic therapy (PDT)-mediated oxidation treatment is extremely attractive for skin
melanoma ablation, but the strong hydrophobicity and poor tumor selectivity of …

A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines

L Wang, L Yang, F Zhang, X Liu, Q Xie, Q Liu… - Cell Reports Physical …, 2023 - cell.com
Seasonal influenza A viruses continue to pose a public health threat, and current vaccines
are not sufficiently effective because of virus mutation. There is an urgent need to develop a …