Androgenic steroids are required to maintain the prostate gland in the adult state. Consistent
with this requirement, androgen deprivation therapies typically induce a drastic regression of …

The response of the prostate tissue microenvironment to androgen deprivation (AD)
represents a critical component in the treatment of benign prostatic hyperplasia and prostate …

PURPOSE: The antivascular effects of androgen deprivation have been investigated in
animal models; however, there has been minimal investigation in human prostate cancer …

BACKGROUND The progesterone receptor, like the androgen receptor, belongs to the
steroid receptor superfamily. Our previous studies have reported that the PR is expressed …

Recent studies have found that blood flow to the rat ventral prostate gland is drastically
reduced at an early time after castration. These observations caused us to reevaluate the …

In the present study we aimed to demonstrate the efficacy of short-term pretreatment with
finasteride in patients undergoing transurethral resection of the prostate (TUR-P). For this …

Tumor growth is limited in size without the incorporation of new blood vessels. Tumor cells
release soluble factors (angiogenic factors) that induce neovascularization and allow …

Simple Summary Therapies that inhibit androgen receptor signaling induce cell death by
apoptosis in prostate epithelium and involution of non-malignant prostate gland, but are not …

BACKGROUND Castration‐induced involution of the normal prostate is caused by primary
effects in the prostate stroma and vasculature, but if this is the case also in tumors is …

Background Androgen ablation is the standard treatment for advanced prostate cancer but
the short‐term cellular effects are largely unknown. Methods Sextant prostate biopsies were …