Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Gastrointestinal side effects (SEs) are frequently observed in patients with major depressive
disorder (MDD) while taking antidepressants and may lead to treatment discontinuation. The …

Abstract Background A 12-week, double-blind, parallel, multi-center randomized controlled
trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate …

Genetic variation can affect drug response in multiple ways, although it remains unclear how
rare genetic variants affect drug response. The electronic Medical Records and Genomics …

Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

The accrual and analysis of genomic sequencing data have identified specific genetic
variants that are associated with major depressive disorder. Moreover, substantial …

Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are
growth factors with trophic effects on neurons. BDNF is the most widely distributed …

Gene-by-environment interactions (G× Es) can provide important biological insights into
psychiatric disorders and may consequently have direct clinical implications. In this review …