Antibiotics are the commonest cause of life-threatening immune-mediated drug reactions
that are considered off-target, including anaphylaxis, and organ-specific and severe …

Controversies exist with regard to in vivo approaches to delayed immunologically mediated
adverse drug reactions, such as exanthem (maculopapular eruption), drug reaction with …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening,
immunologically mediated, and usually drug-induced disease with a high burden to …

The overlabeling of pediatric antibiotic allergy represents a huge burden in society. Given
that up to 10% of the US population is labeled as penicillin allergic, it can be estimated that …

Delayed drug hypersensitivity reactions are clinically diverse reactions that vary from
isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug …

Background Direct drug provocation test (DPT) without prior skin testing (ST) has been
investigated in children suspected of being at risk for beta-lactam (BL) hypersensitivity …

Antibiotic allergy labeling is highly prevalent and negatively impacts patient outcomes and
antibiotic appropriateness. Reducing the prevalence and burden of antibiotic allergies …

Stevens–Johnson syndrome and toxic epidermal necrolysis are rare severe blistering skin
reactions triggered by medications or infections. Over the last 5 to 10 years, a number of …