Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Recent advances in body-on-a-chip systems
Microphysiological systems (MPS, also known as “organ-on-a-chip”,“body-on-a-chip”, or
“human-on-a-chip”) have emerged over the last 15 years as attractive systems to probe …
“human-on-a-chip”) have emerged over the last 15 years as attractive systems to probe …
Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach?
GA Van Norman - JACC: Basic to Translational Science, 2019 - jacc.org
Animal testing is used in pharmaceutical and industrial research to predict human toxicity,
and yet analysis suggests that animal models are poor predictors of drug safety in humans …
and yet analysis suggests that animal models are poor predictors of drug safety in humans …
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip
S Musah, A Mammoto, TC Ferrante… - Nature biomedical …, 2017 - nature.com
An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a …
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a …
[HTML][HTML] Animal models in biological and biomedical research-experimental and ethical concerns
ML Andersen, LMF Winter - Anais da Academia Brasileira de Ciências, 2017 - SciELO Brasil
Animal models have been used in experimental research to increase human knowledge
and contribute to finding solutions to biological and biomedical questions. However …
and contribute to finding solutions to biological and biomedical questions. However …
An overview of animal models related to schizophrenia
Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …
therapies. In this brief review, we provide an update regarding the use of animal models to …
Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …
biomimetic principles to create key aspects of living organs faithfully, including critical …
[HTML][HTML] High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases
Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …
Design and demonstration of a pumpless 14 compartment microphysiological system
PG Miller, ML Shuler - Biotechnology and bioengineering, 2016 - Wiley Online Library
We describe a human “Body‐on‐a‐chip” device (or microphysiological system) that could be
used to emulate drug distribution, metabolism, and action in the body. It is based upon a …
used to emulate drug distribution, metabolism, and action in the body. It is based upon a …
Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip
Protocols have been established to direct the differentiation of human induced pluripotent
stem (iPS) cells into nephron progenitor cells and organoids containing many types of …
stem (iPS) cells into nephron progenitor cells and organoids containing many types of …