A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

In humans born at term, maximal nephron number is reached by the time nephrogenesis is
completed—at approximately 36 weeks' gestation. The number of nephrons does not …

Despite significant advances in understanding nephron segment patterning, many questions
remain about the underlying genes and signaling pathways that orchestrate renal progenitor …

Chronic kidney disease (CKD) is a major healthcare issue worldwide. However, the
prevalence of pediatric CKD has never been systematically assessed and consistent …

The effects of bismuth toxicity on the kidney—the main organ responsible for blood filtration—
were systematically reviewed. This review was motivated by availability of several sources of …

Climate change has important impacts on pregnant women and their unborn children. Being
born too small or too soon is associated with life-time risk of kidney disease. Climate change …

Background Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers
of kidney function that have been used variously to define stable vs progressive chronic …

Controlling the time and place of nephron formation in vitro would improve nephron density
and connectivity in next-generation kidney replacement tissues. Recent developments in …

Background Congenital anomalies of the kidney and urinary tract (CAKUT) are the most
frequent causes of childhood chronic kidney disease (CKD). Using a large CAKUT cohort …

Objective To describe the blood pressure outcomes of infants admitted to the neonatal
intensive care unit (NICU) with idiopathic (nonsecondary) hypertension (HTN) who were …