The blood–retina barrier in health and disease

F O'Leary, M Campbell - The FEBS journal, 2023 - Wiley Online Library
The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

Pericyte-endothelial interactions in the retinal microvasculature

H Huang - International journal of molecular sciences, 2020 - mdpi.com
Retinal microvasculature is crucial for the visual function of the neural retina. Pericytes and
endothelial cells (ECs) are the two main cellular constituents in the retinal microvessels …

Retinal findings in hospitalised patients with severe COVID-19

LA Pereira, LCM Soares, PA Nascimento… - British Journal of …, 2022 - bjo.bmj.com
Aim To identify retinal findings using dilated eye examination, which are possibly related to
SARS-CoV-2 infection in hospitalised patients with confirmed severe COVID-19. Methods In …

Molecular mechanism of VEGF and its role in pathological angiogenesis

A Ahmad, MI Nawaz - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …

Paracentral acute middle maculopathy and the organization of the retinal capillary plexuses

J Scharf, KB Freund, SV Sadda, D Sarraf - Progress in retinal and eye …, 2021 - Elsevier
The retinal capillary vasculature serves the formidable role of supplying the metabolically
active inner and middle retina. In the parafoveal region, the retinal capillary plexuses (RCP) …

Roles of HIFs and VEGF in angiogenesis in the retina and brain

A Rattner, J Williams, J Nathans - The Journal of clinical …, 2019 - Am Soc Clin Investig
Vascular development in the mammalian retina is a paradigm for CNS vascular
development in general, and its study is revealing fundamental mechanisms that explain the …

The impact of oxidative stress on blood-retinal barrier physiology in age-related macular degeneration

A Tisi, M Feligioni, M Passacantando, M Ciancaglini… - Cells, 2021 - mdpi.com
The blood retinal barrier (BRB) is a fundamental eye component, whose function is to select
the flow of molecules from the blood to the retina and vice-versa, and its integrity allows the …

Age-related macular degeneration: role of oxidative stress and blood vessels

Y Ruan, S Jiang, A Gericke - International journal of molecular sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

Oxidative stress and vascular dysfunction in the retina: Therapeutic strategies

Y Ruan, S Jiang, A Musayeva, A Gericke - Antioxidants, 2020 - mdpi.com
Many retinal diseases, such as diabetic retinopathy, glaucoma, and age-related macular
(AMD) degeneration, are associated with elevated reactive oxygen species (ROS) levels …

Wnt Signaling in vascular eye diseases

Z Wang, CH Liu, S Huang, J Chen - Progress in retinal and eye research, 2019 - Elsevier
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …