The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Androgen receptor (AR) is closely associated with a group of hormone‐related diseases
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …

Herein, we examine the complexation and biological delivery of a short single-stranded
antisense oligonucleotide (ASO) payload with four polymer derivatives that form two …

The incidence of glioma in men is higher than that in women; however, little is known about
the expression and basic function of the androgen receptor (AR) in gliomas. AR inhibited the …

Introduction Metastatic castration-resistant prostate cancer (CRPC) is a potentially
symptomatic disease with an eventual lethal outcome. Novel pharmaceutical agents are …

Prostate cancer affects an increasing number of men worldwide and is a leading cause of
cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including …

We report herein, the discovery of BMS-737 (compound 33) as a potent, non-steroidal,
reversible small molecule inhibitor demonstrating 11-fold selectivity for CYP17 lyase over …

ABSTRACT Introduction: Prostate cancer (PCa) is the most common cancer in elderly males.
Androgen deprivation therapy (ADT) is still the cornerstone of initial treatment; however, the …

Introduction: Prostate cancer is the most common cancer in men. Regardless of the initial
treatment of localized disease, almost all patients develop castration resistant prostate …

Advanced prostate cancer can develop into castration-resistant prostate cancer (CRPC).
This process is mediated either by intratumoral ligand synthesis or by mutations or …