As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …

The efficiency of clinical trials involving transplantation of multipotent mesenchymal stromal
cells (MSCs) is often insufficient due to harsh conditions present within the target tissue …

Mesenchymal stromal/stem cells (MSCs) have been investigated extensively through the
past years, proving to have great clinical therapeutic potential. In vitro cultivation of MSCs in …

Introduction: One of the key factors that may influence the therapeutic potential of
mesenchymal stem/stromal cells (MSCs) is their metabolism. The switch between …

Ischemic diseases such as myocardial infarction, ischemic stroke, and critical limb ischemia
are immense public health challenges. Current pharmacotherapy and surgical approaches …

Mesenchymal stem cells (MSCs) are considered as primary candidates for cell-based
therapies due to their multiple effects in regenerative medicine. Pre-conditioning of MSCs …

Stem cell therapy has emerged as a promising regenerative medicine strategy but is limited
by poor cell survival, leading to low therapeutic outcomes. We developed cell spheroid …

Background aims Cell-based therapies have made an impact on the treatment of
osteoarthritis; however, the repair and regeneration of thick cartilage defects is an important …

Three-dimensional culture of mesenchymal stem/stromal cells for spheroid formation is
known to enhance their therapeutic potential for regenerative medicine. Spheroids were …

The aim of this study was to investigate the effects of low-level laser therapy (LLLT) on
transplanted human adipose-derived mesenchymal stem cells (hASCs) spheroid in a hind …