Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled
by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis …

Prostate cancer is one of the major causes of cancer-related death in the western world.
Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the …

The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …

Dysregulation of androgen signaling and pericellular proteolysis is necessary for prostate
cancer progression, but the links between them are still obscure. In this study, we show how …

Yes-associated protein (YAP) is an effector of the Hippo tumor suppressor pathway. The
functional significance of YAP in prostate cancer has remained elusive. In this study, we first …

The proliferation and differentiation of normal prostate epithelial cells depends upon the
action of androgens produced by the testis. Prostate cancers retain the ability to respond to …

Neuroendocrine (NE) cells are the minor cell populations in normal prostate epithelial
compartments. During prostate carcinogenesis, the number of NE cells in malignant lesions …

Prostate cancer is the most common malignancy and the second leading cause of cancer-
related deaths in men. One common treatment is androgen-deprivation therapy, which …

Purpose: The transcription factor nuclear factor-κB (NF-κB) promotes the production of
angiogenic, antiapoptotic, and prometastatic factors that are involved in carcinogenesis …