Glial cells in schizophrenia: a unified hypothesis
The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …
neuroimaging studies, pathological findings, and experimental work supporting the idea that …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
[PDF][PDF] Genetic control of expression and splicing in developing human brain informs disease mechanisms
Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …
Synergistic effects of common schizophrenia risk variants
The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
[PDF][PDF] Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
The hippocampus formation, although prominently implicated in schizophrenia
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
Research domain criteria: strengths, weaknesses, and potential alternatives for future psychiatric research
CA Ross, RL Margolis - Complex Psychiatry, 2019 - karger.com
Abstract The Research Domain Criteria (RDoC) paradigm was launched 10 years ago as a
superior approach for investigation of mental illness. RDoC conceptualizes normal human …
superior approach for investigation of mental illness. RDoC conceptualizes normal human …
Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids
T Sawada, TE Chater, Y Sasagawa, M Yoshimura… - Molecular …, 2020 - nature.com
Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms
underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress …
underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress …
Developmental dynamics of RNA translation in the human brain
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity
and cognitive function. Although several studies have profiled transcription in the developing …
and cognitive function. Although several studies have profiled transcription in the developing …