Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression

RJ Strawbridge, J Ward, LM Lyall, EM Tunbridge… - Translational …, 2018 - nature.com
Risk-taking behaviour is an important component of several psychiatric disorders, including
attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two …

Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk

C Zhang, X Li, L Zhao, W Guo, W Deng… - Psychological …, 2023 - cambridge.org
BackgroundTo identify risk genes whose expression are regulated by the reported risk
variants and to explore the potential regulatory mechanism in schizophrenia (SCZ) …

The genesis of schizophrenia: an origin story

R Birnbaum, DR Weinberger - American Journal of Psychiatry, 2024 - Am Psychiatric Assoc
Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of
brain development in a disorder typically diagnosed during early adult life is enigmatic. The …

Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus

KJM Benjamin, R Arora, AS Feltrin, G Pertea… - Nature …, 2024 - nature.com
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features,
including differential symptomatology, drug responsiveness, and male incidence rate. Prior …

Thinking about schizophrenia in an era of genomic medicine

DR Weinberger - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
Genetic discoveries about human brain development and neuropsychiatric syndromes have
changed the landscape of psychiatric research. The genotyping of hundreds of thousands of …

[HTML][HTML] Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain

C Wen, M Margolis, R Dai, P Zhang, PF Przytycki… - medRxiv, 2023 - ncbi.nlm.nih.gov
Genomic regulatory elements active in the developing human brain are notably enriched in
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …

An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data

CY Zhang, X Xiao, Z Zhang, Z Hu, M Li - Molecular Psychiatry, 2022 - nature.com
Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has
been extensively described. Nevertheless, the alternative splicing characteristics of the …

Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia

PJM Deans, KJ Brennand - Current opinion in neurobiology, 2021 - Elsevier
Schizophrenia is a highly heritable, polygenic disorder. A growing list of common genetic
variants have been associated with schizophrenia; there is a clear need to understand the …

Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting

R Afridi, S Seol, HJ Kang, K Suk - Biochemical Pharmacology, 2021 - Elsevier
Understanding the pathophysiological mechanisms of neuropsychiatric disorders has been
a challenging quest for neurobiologists. Recent years have witnessed enormous …

[HTML][HTML] The genetic overlap between Alzheimer's disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson's disease

DP Wightman, JE Savage, E Tissink, C Romero… - Neurobiology of …, 2023 - Elsevier
Neurodegenerative diseases are a group of disorders characterized by neuronal cell death
causing a variety of physical and mental problems. While these disorders can be …