Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression
Risk-taking behaviour is an important component of several psychiatric disorders, including
attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two …
attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two …
Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk
C Zhang, X Li, L Zhao, W Guo, W Deng… - Psychological …, 2023 - cambridge.org
BackgroundTo identify risk genes whose expression are regulated by the reported risk
variants and to explore the potential regulatory mechanism in schizophrenia (SCZ) …
variants and to explore the potential regulatory mechanism in schizophrenia (SCZ) …
The genesis of schizophrenia: an origin story
R Birnbaum, DR Weinberger - American Journal of Psychiatry, 2024 - Am Psychiatric Assoc
Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of
brain development in a disorder typically diagnosed during early adult life is enigmatic. The …
brain development in a disorder typically diagnosed during early adult life is enigmatic. The …
Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features,
including differential symptomatology, drug responsiveness, and male incidence rate. Prior …
including differential symptomatology, drug responsiveness, and male incidence rate. Prior …
Thinking about schizophrenia in an era of genomic medicine
DR Weinberger - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
Genetic discoveries about human brain development and neuropsychiatric syndromes have
changed the landscape of psychiatric research. The genotyping of hundreds of thousands of …
changed the landscape of psychiatric research. The genotyping of hundreds of thousands of …
[HTML][HTML] Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain
Genomic regulatory elements active in the developing human brain are notably enriched in
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …
An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
CY Zhang, X Xiao, Z Zhang, Z Hu, M Li - Molecular Psychiatry, 2022 - nature.com
Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has
been extensively described. Nevertheless, the alternative splicing characteristics of the …
been extensively described. Nevertheless, the alternative splicing characteristics of the …
Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia
PJM Deans, KJ Brennand - Current opinion in neurobiology, 2021 - Elsevier
Schizophrenia is a highly heritable, polygenic disorder. A growing list of common genetic
variants have been associated with schizophrenia; there is a clear need to understand the …
variants have been associated with schizophrenia; there is a clear need to understand the …
Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting
Understanding the pathophysiological mechanisms of neuropsychiatric disorders has been
a challenging quest for neurobiologists. Recent years have witnessed enormous …
a challenging quest for neurobiologists. Recent years have witnessed enormous …
[HTML][HTML] The genetic overlap between Alzheimer's disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson's disease
Neurodegenerative diseases are a group of disorders characterized by neuronal cell death
causing a variety of physical and mental problems. While these disorders can be …
causing a variety of physical and mental problems. While these disorders can be …