Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …

Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding
how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and …

Background: It is important to identify patients with monogenic IBD as management may
differ from classical IBD. In this position statement we formulate recommendations for the …

The mammalian immune system uses various pattern recognition receptors to recognize
invaders and host damage and transmits this information to downstream immunometabolic …

Biallelic loss-of-function (LOF) mutations of the NCF4 gene, encoding the p40 phox subunit
of the phagocyte NADPH oxidase, have been described in only 1 patient. We report on 24 …

Background & Aims A proportion of infants and young children with inflammatory bowel
diseases (IBDs) have subtypes associated with a single gene variant (monogenic IBD). We …

Genomic technologies inform the complex genetic basis of polygenic inflammatory bowel
disease (IBD) as well as Mendelian disease-associated IBD. Aiming to diagnose patients …

Owing to advances in genomics that enable differentiation of molecular aetiologies, patients
with monogenic inflammatory bowel disease (mIBD) potentially have access to genotype …

A number of diseases and conditions have been associated with prolonged or persistent
exposure to non-physiological levels of reactive oxygen species (ROS). Similarly, ROS …

Objective Loss-of-function mutations in genes generating reactive oxygen species (ROS),
such as NOX1, are associated with IBD. Mechanisms whereby loss of ROS drive IBD are …