Transforming growth factor-beta signaling in cancer-induced cachexia: from molecular pathways to the clinics

R Balsano, Z Kruize, M Lunardi, A Comandatore… - Cells, 2022 - mdpi.com
Cachexia is a metabolic syndrome consisting of massive loss of muscle mass and function
that has a severe impact on the quality of life and survival of cancer patients. Up to 20% of …

Natural products: Potential therapeutic agents to prevent skeletal muscle atrophy

A Yadav, SS Yadav, S Singh, R Dabur - European Journal of …, 2022 - Elsevier
The skeletal muscle (SkM) is the largest organ, which plays a vital role in controlling
musculature, locomotion, body heat regulation, physical strength, and metabolism of the …

Nutritional and exercise interventions in cancer-related cachexia: an extensive narrative review

VJ Clemente-Suárez, L Redondo-Flórez… - International Journal of …, 2022 - mdpi.com
One of the common traits found in cancer patients is malnutrition and cachexia, which affects
between 25% to 60% of the patients, depending on the type of cancer, diagnosis, and …

Chemotherapy-induced myopathy: the dark side of the cachexia sphere

DG Campelj, CA Goodman, E Rybalka - Cancers, 2021 - mdpi.com
Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …

Exercise medicine for cancer cachexia: Targeted exercise to counteract mechanisms and treatment side effects

G Mavropalias, M Sim, DR Taaffe, DA Galvão… - Journal of Cancer …, 2022 - Springer
Purpose Cancer-induced muscle wasting (ie, cancer cachexia, CC) is a common and
devastating syndrome that results in the death of more than 1 in 5 patients. Although …

Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review

AF Bakr, P Shao, MA Farag - Phytomedicine, 2022 - Elsevier
Background Glycyrrhizin (GL) is a major active constituent of licorice root (Glycyrrhiza
glabra) that is considered one of the oldest and most frequently employed botanicals in …

Targeting mitochondria and oxidative stress in cancer-and chemotherapy-induced muscle wasting

JR Huot, D Baumfalk, A Resendiz… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

Quercetin improved muscle mass and mitochondrial content in a murine model of cancer and chemotherapy-induced cachexia

BN VanderVeen, TD Cardaci, P Cunningham… - Nutrients, 2022 - mdpi.com
A cachexia diagnosis is associated with a doubling in hospital stay and increased
healthcare cost for cancer patients and most cachectic patients do not survive treatment …

[HTML][HTML] Molecular mechanisms of cancer cachexia. Role of exercise training

E Tamayo-Torres, A Garrido, R de Cabo… - Molecular Aspects of …, 2024 - Elsevier
Cancer-associated cachexia represents a multifactorial syndrome mainly characterized by
muscle mass loss, which causes both a decrease in quality of life and anti-cancer therapy …

Exercise counteracts the deleterious effects of cancer cachexia

S Tsitkanou, KA Murach, TA Washington, NP Greene - Cancers, 2022 - mdpi.com
Simple Summary This review provides an overview of the effects of exercise training on the
major mechanisms related to cancer cachexia (CC). The review also discusses how cancer …