Importance of the pig as a human biomedical model
JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
[HTML][HTML] Natural and synthetic antioxidants targeting cardiac oxidative stress and redox signaling in cardiometabolic diseases
M Barteková, A Adameová, A Görbe… - Free Radical Biology …, 2021 - Elsevier
Cardiometabolic diseases (CMDs) are metabolic diseases (eg, obesity, diabetes,
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …
Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents
In this study, procyanidins fractions of dimers and trimers (F1–F2) from the Leucosidea
sericea total extract (LSTE) were investigated for their chemical constituents. The total …
sericea total extract (LSTE) were investigated for their chemical constituents. The total …
[HTML][HTML] A transcriptional cross species map of pancreatic islet cells
Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …
Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus
TA Lutz - Nature Reviews Endocrinology, 2023 - nature.com
Although no single animal model replicates all aspects of diabetes mellitus in humans,
animal models are essential for the study of energy balance and metabolism control as well …
animal models are essential for the study of energy balance and metabolism control as well …
Effect of metformin on testosterone levels in male patients with type 2 diabetes mellitus treated with insulin
T Cai, Y Hu, B Ding, R Yan, B Liu, L Cai… - Frontiers in …, 2021 - frontiersin.org
Aim To explore the chronic effects of metformin on testosterone levels in men with type 2
diabetes mellitus (T2DM). Methods This is a secondary analysis of a real-world study …
diabetes mellitus (T2DM). Methods This is a secondary analysis of a real-world study …
[HTML][HTML] Preclinical models of diabetic wound healing: A critical review
The treatment of diabetic wounds (DWs) is always challenging for the medical community
because of its multifaceted pathophysiology. Due to practical and ethical considerations …
because of its multifaceted pathophysiology. Due to practical and ethical considerations …
Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality
F Lezoualc'h, L Badimon, H Baker… - Cardiovascular …, 2023 - academic.oup.com
Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery
disease, and valvular or congenital heart disease, is now recognized as a distinct …
disease, and valvular or congenital heart disease, is now recognized as a distinct …
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model
B Shashikadze, L Valla, SD Lombardo, C Prehn… - Molecular …, 2023 - Elsevier
Objective To gain mechanistic insights into adverse effects of maternal hyperglycemia on the
liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed …
liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed …
Identification of candidate genes that specifically regulate subcutaneous and intramuscular fat deposition using transcriptomic and proteomic profiles in Dingyuan pigs
P Zhang, Q Li, Y Wu, Y Zhang, B Zhang, H Zhang - Scientific reports, 2022 - nature.com
Subcutaneous fat and intramuscular fat (IMF) deposition are closely related to meat
production and pork quality. Dingyuan pig, as a native pig breed in China, low selection …
production and pork quality. Dingyuan pig, as a native pig breed in China, low selection …