Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

[HTML][HTML] Natural and synthetic antioxidants targeting cardiac oxidative stress and redox signaling in cardiometabolic diseases

M Barteková, A Adameová, A Görbe… - Free Radical Biology …, 2021 - Elsevier
Cardiometabolic diseases (CMDs) are metabolic diseases (eg, obesity, diabetes,
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

UM Badeggi, E Ismail, AO Adeloye, S Botha… - Biomolecules, 2020 - mdpi.com
In this study, procyanidins fractions of dimers and trimers (F1–F2) from the Leucosidea
sericea total extract (LSTE) were investigated for their chemical constituents. The total …

[HTML][HTML] A transcriptional cross species map of pancreatic islet cells

S Tritschler, M Thomas, A Böttcher, B Ludwig… - Molecular …, 2022 - Elsevier
Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …

Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus

TA Lutz - Nature Reviews Endocrinology, 2023 - nature.com
Although no single animal model replicates all aspects of diabetes mellitus in humans,
animal models are essential for the study of energy balance and metabolism control as well …

Effect of metformin on testosterone levels in male patients with type 2 diabetes mellitus treated with insulin

T Cai, Y Hu, B Ding, R Yan, B Liu, L Cai… - Frontiers in …, 2021 - frontiersin.org
Aim To explore the chronic effects of metformin on testosterone levels in men with type 2
diabetes mellitus (T2DM). Methods This is a secondary analysis of a real-world study …

[HTML][HTML] Preclinical models of diabetic wound healing: A critical review

BKR Sanapalli, V Yele, MK Singh… - Biomedicine & …, 2021 - Elsevier
The treatment of diabetic wounds (DWs) is always challenging for the medical community
because of its multifaceted pathophysiology. Due to practical and ethical considerations …

Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality

F Lezoualc'h, L Badimon, H Baker… - Cardiovascular …, 2023 - academic.oup.com
Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery
disease, and valvular or congenital heart disease, is now recognized as a distinct …

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

B Shashikadze, L Valla, SD Lombardo, C Prehn… - Molecular …, 2023 - Elsevier
Objective To gain mechanistic insights into adverse effects of maternal hyperglycemia on the
liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed …

Identification of candidate genes that specifically regulate subcutaneous and intramuscular fat deposition using transcriptomic and proteomic profiles in Dingyuan pigs

P Zhang, Q Li, Y Wu, Y Zhang, B Zhang, H Zhang - Scientific reports, 2022 - nature.com
Subcutaneous fat and intramuscular fat (IMF) deposition are closely related to meat
production and pork quality. Dingyuan pig, as a native pig breed in China, low selection …