The biology of solid tumors is strongly determined by the interactions of cancer cells with
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …

Simple Summary In pancreatic cancer, immunotherapy and targeted therapies have not
brought about the therapeutic revolution that has been observed in other malignancies …

Simple Summary This review article presents a synopsis of the key clinical developments,
their limitations, and future perspectives in the treatment of pancreatic cancer. In the first part …

Background: Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in
various anticancer therapies. Immuno-inflammatory response is considered to be a major …

BACKGROUND Natural cytotoxicity, mediated by natural killer (NK) cells and cells with
lymphokine‐activated killer (LAK) activity, is believed to play an important role in host anti …

The immune system plays a complex role in the development and progression of pancreatic
cancer. Inflammation can promote the formation of premalignant lesions and accelerate …

Background Recently, natural killer (NK) cells emerged as a treatment option for various
solid tumors. However, the immunosuppressive tumor immune microenvironment (TIME) …

Experimental and clinical experience demonstrates that the resolution of a pathogenic
challenge depends not only on the presence or absence of an immune reaction, but also on …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common tumor subtypes and
remains associated with very poor survival. T cell infiltration into tumor tissue is associated …

OBJECTIVE: Natural cytotoxicity, mediated by natural killer (NK) cells, has been believed to
play an important role in inhibiting experimental tumor metastasis, and diminished NK cell …