In addition to exerting several essential house-keeping activities in the cell, heat shock
proteins (HSPs) are crucial players in a well-structured molecular program activated in …

“Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not
formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone …

The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300
client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate …

For decades, the undisputable definition of the cytosolic Hsp90α and hsp90β proteins being
evolutionarily conserved, ATP-driven chaperones has ruled basic research and clinical …

Background The role of plasma heat shock protein 90alpha (Hsp90α) in gastric cancers
remains unclear. This study aimed to clarify the diagnostic and prognostic value of plasma …

Aim: We investigated the effect of the combination of heat shock protein 90α (HSP90α),
alpha-fetoprotein (AFP) and thymidine kinase 1 (TK1) in the diagnosis of hepatocellular …

Neocryptolepine derivatives have attracted great interest because of their unique cytotoxic
activity. 8-Fluoroneocryptolepine (8FNC) was synthesized, and its cytotoxicity was evaluated …

Background AT-533 is a novel heat shock protein 90 inhibitor that exerting anti-
inflammatory, antiviral, and antitumor efficacy. Furthermore, the gel made of AT-533 as raw …

Laryngeal squamous cell carcinoma (LSCC) constitutes a noteworthy subset of head and
neck cancers, contributing to about 4.5% of all malignancies. Its clinical behavior and …

Objective To explore the possible mechanisms by which follicle-stimulating hormone (FSH)
regulates postmenopausal osteoporosis through the FSH/FSH receptor (FSHr)/G …