The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

The epidermis closely interacts with nerve endings, and both epidermis and nerves produce
substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin …

Rosacea is a chronic inflammatory skin condition that affects approximately 16 million
Americans. Four distinct subtypes of rosacea have been recognized, with transient and …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

Rosacea is a chronic inflammatory skin disease of unknown etiology. Although described
centuries ago, the pathophysiology of this disease is still poorly understood. Epidemiological …

The necessity of safe and effective treatments for chronic pain has intensified the search for
new analgesic drugs. In the last few years, members of a closely-related family of ion …

α-Calcitonin gene–related peptide (αCGRP) is a vasodilator, but there is limited knowledge
of its long-term cardiovascular protective influence. We hypothesized that αCGRP protects …

Neurogenic inflammation is involved in skin inflammation. It is hypothesized that it is
involved in the pathogenesis of the common chronic cutaneous vascular disorder rosacea …

The cold-induced vascular response, consisting of vasoconstriction followed by
vasodilatation, is critical for protecting the cutaneous tissues against cold injury. Whilst this …