When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

Since detection of an RNA molecule is the major criterion to define transcriptional activity,
the fraction of the genome that is expressed is generally considered to parallel the …

The carboxy-terminal domain (CTD) of the RNA polymerase II (RNApII) largest subunit
consists of multiple heptapeptide repeats with the consensus sequence YSPTSPS. Different …

RNA turnover is an integral part of cellular RNA homeostasis and gene expression
regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of …

Eukaryotic cells contain numerous RNA quality-control systems that are important for
shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation …

The exosome complex plays a central and essential role in RNA metabolism. However,
comprehensive studies of exosome substrates and functional analyses of its subunits are …

Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine
control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for …

The exosome complex is involved in multiple RNA processing and degradation pathways.
How exosome is recruited to particular RNA substrates and then chooses between RNA …

Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment to …