Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

NA Terrault, ASF Lok, BJ McMahon, KM Chang… - …, 2018 - Wiley Online Library
This AASLD 2018 Hepatitis B Guidance is intended to complement the AASLD 2016
Practice Guidelines for Treatment of Chronic Hepatitis B (1) and update the previous …

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

M Thursz, A Gual, C Lackner, P Mathurin, C Moreno… - Journal of …, 2018 - Elsevier
The harmful use of alcohol has been estimated to cause approximately 3.3 million deaths
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …

[HTML][HTML] Limitations of non-invasive tests for assessment of liver fibrosis

K Patel, G Sebastiani - JHEP Reports, 2020 - Elsevier
The diagnostic assessment of liver injury is an important step in the management of patients
with chronic liver disease (CLD). Although liver biopsy is the reference standard for the …

Magnetic resonance vs transient elastography analysis of patients with nonalcoholic fatty liver disease: a systematic review and pooled analysis of individual …

C Hsu, C Caussy, K Imajo, J Chen, S Singh… - Clinical …, 2019 - Elsevier
Background & Aims Magnetic resonance elastography (MRE) and transient elastography
(TE) are noninvasive techniques for detection of liver fibrosis. Single-center studies have …

Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease

R Ramanathan, AH Ali, JA Ibdah - International Journal of Molecular …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …

Incidence of hepatocellular carcinoma in patients with HCV-associated cirrhosis treated with direct-acting antiviral agents

V Calvaruso, G Cabibbo, I Cacciola, S Petta… - Gastroenterology, 2018 - Elsevier
Background & Aims Studies have produced conflicting results of the incidence of
hepatocellular carcinoma (HCC) in patients with hepatitis C virus–associated cirrhosis …

[PDF][PDF] Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease

S Augustin, M Pons, JB Maurice, C Bureau… - …, 2017 - Wiley Online Library
Patients with compensated advanced chronic liver disease (cACLD) can safely avoid
screening endoscopy with a platelet count> 150× 109 cells/L and a liver stiffness …

[HTML][HTML] High prevalence of liver fibrosis among European adults with unknown liver disease: a population-based study

L Caballería, G Pera, I Arteaga, L Rodríguez… - Clinical …, 2018 - Elsevier
Background & Aims Liver fibrosis is the main determinant of long-term outcome in chronic
liver diseases. Little is known about the prevalence of liver fibrosis in the general population …

Fibrosis regression after eradication of hepatitis C virus: from bench to bedside

DC Rockey, SL Friedman - Gastroenterology, 2021 - Elsevier
Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …

[PDF][PDF] Programmed cell death‐1 (PD‐1) checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma …

H Li, X Li, S Liu, L Guo, B Zhang, J Zhang, Q Ye - Hepatology, 2017 - Wiley Online Library
Inhibitors of programmed cell death 1 (PD‐1) administered as single agents have resulted in
durable tumor regression in advanced cancer patients. However, only a minority of cancer …