T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Metabolic signaling in T cells
The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …
biochemical molecules between organ systems, their composite cells, and subcellular …
Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment
H Harjunpää, M Llort Asens, C Guenther… - Frontiers in …, 2019 - frontiersin.org
The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …
playing a dual role in tumor development. The effector cells of the immune system can …
Bispecific T cell engagers: an emerging therapy for management of hematologic malignancies
Z Tian, M Liu, Y Zhang, X Wang - Journal of hematology & oncology, 2021 - Springer
Harnessing the power of immune cells, especially T cells, to enhance anti-tumor activities
has become a promising strategy in clinical management of hematologic malignancies. The …
has become a promising strategy in clinical management of hematologic malignancies. The …
Phase separation in immune signalling
Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …
resolution of infection. Upon ligand engagement, immune receptors together with their …
Liquid phase condensation in cell physiology and disease
Y Shin, CP Brangwynne - Science, 2017 - science.org
BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …
regulation of biological reactions. In addition to canonical membrane-bound organelles such …
TFOS DEWS II management and therapy report
The members of the Management and Therapy Subcommittee undertook an evidence-
based review of current dry eye therapies and management options. Management options …
based review of current dry eye therapies and management options. Management options …
Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation
A Le Floc'h, J Allinne, K Nagashima, G Scott… - Allergy, 2020 - Wiley Online Library
Background Dupilumab, a fully human monoclonal antibody that binds IL‐4Rα and inhibits
signaling of both IL‐4 and IL‐13, has shown efficacy across multiple diseases with …
signaling of both IL‐4 and IL‐13, has shown efficacy across multiple diseases with …
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies
B Greco, V Malacarne, F De Girardi, GM Scotti… - Science translational …, 2022 - science.org
Immunotherapy with chimeric antigen receptor (CAR)–engineered T cells showed
exceptional successes in patients with refractory B cell malignancies. However, first-in …
exceptional successes in patients with refractory B cell malignancies. However, first-in …
Optimized tandem CD19/CD20 CAR-engineered T cells in refractory/relapsed B-cell lymphoma
C Tong, Y Zhang, Y Liu, X Ji, W Zhang… - Blood, The Journal …, 2020 - ashpublications.org
Chimeric antigen receptor (CAR) T cells targeting CD19 have achieved breakthroughs in the
treatment of hematological malignancies, such as relapsed/refractory non-Hodgkin …
treatment of hematological malignancies, such as relapsed/refractory non-Hodgkin …