Cellular senescence and SASP in tumor progression and therapeutic opportunities
Z Dong, Y Luo, Z Yuan, Y Tian, T Jin, F Xu - Molecular Cancer, 2024 - Springer
Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and
proliferation leading to the degeneration of cellular structure and function, has been …
proliferation leading to the degeneration of cellular structure and function, has been …
The potential of senescence as a target for developing anticancer therapy
H Jo, K Shim, D Jeoung - International Journal of Molecular Sciences, 2023 - mdpi.com
Senescence occurs in response to various stimuli. Senescence has attracted attention
because of its potential use in anticancer therapy as it plays a tumor-suppressive role. It also …
because of its potential use in anticancer therapy as it plays a tumor-suppressive role. It also …
The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene
E Vickridge, CCF Faraco, F Lo, H Rahimian… - Nucleic acids …, 2024 - academic.oup.com
Genetic studies in mice and human cancers established BCL11B as a haploinsufficient
tumor suppressor gene. Paradoxically, BCL11B is overexpressed in some human cancers …
tumor suppressor gene. Paradoxically, BCL11B is overexpressed in some human cancers …
Causal associations and genetic overlap between COVID-19 and intelligence
Objective COVID-19 might cause neuroinflammation in the brain, which could decrease
neurocognitive function. We aimed to evaluate the causal associations and genetic overlap …
neurocognitive function. We aimed to evaluate the causal associations and genetic overlap …
Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas
K Sarad, M Stefańska, I Kraszewska, K Szade… - Frontiers in …, 2023 - frontiersin.org
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator of antioxidant
and anti-inflammatory response in all cell types. It also activates the transcription of genes …
and anti-inflammatory response in all cell types. It also activates the transcription of genes …
The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase
T Petrachkova, O Soldatkina, L Leduy… - Biological …, 2024 - degruyter.com
The BCL11A transcription factor has previously been shown to interact with and stimulate
the enzymatic activities of the NTHL1 DNA glycosylase and Pol β polymerase. Here we …
the enzymatic activities of the NTHL1 DNA glycosylase and Pol β polymerase. Here we …
[PDF][PDF] Deciphering BRCAness Phenotype in Cancer: A Graph Convolutional Neural Network Approach with Layer-wise Relevance Propagation Analysis
J Yang, H Chereda, J Dönitz… - An automated data …, 2024 - ediss.uni-goettingen.de
Background: Cancer variability among patients underscores the need for personalized
therapy based on genomic understanding. BRCAness, characterized by vulnerabilities …
therapy based on genomic understanding. BRCAness, characterized by vulnerabilities …
Intégration de signaux au niveau de la chromatine et perturbations de la ribogénèse pour une suppression tumorale efficace
S Lopes-Paciencia - 2023 - papyrus.bib.umontreal.ca
Environ 30% des cancers humains ont une mutation gain de fonction dans l'oncogène RAS,
menant à une prolifération cellulaire accrue et une expansion clonale. Cependant, il est …
menant à une prolifération cellulaire accrue et une expansion clonale. Cependant, il est …