Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
Advances in glioblastoma therapy: an update on current approaches
Glioblastoma multiforme (GBM) is a primary malignant brain tumor characterized by a high
grade of malignancy and an extremely unfavorable prognosis. The current efficacy of …
grade of malignancy and an extremely unfavorable prognosis. The current efficacy of …
Targeting RTK-PI3K-mTOR axis in gliomas: An update
M Colardo, M Segatto, S Di Bartolomeo - International Journal of …, 2021 - mdpi.com
Gliomas are the most common and challenging malignancies of the central nervous system
(CNS), due to their infiltrative nature, tendency to recurrence, and poor response to …
(CNS), due to their infiltrative nature, tendency to recurrence, and poor response to …
From signalling pathways to targeted therapies: unravelling glioblastoma's secrets and harnessing two decades of progress
Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …
EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes
R El Baba, S Pasquereau, S Haidar Ahmad, F Monnien… - Oncogene, 2023 - nature.com
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic
virus. HCMV has been detected in malignant gliomas. EZH2 and Myc play a potential …
virus. HCMV has been detected in malignant gliomas. EZH2 and Myc play a potential …
[PDF][PDF] Zieli nski, R
B Pajak - Molecules, 2022 - pdfs.semanticscholar.org
Viral infection almost invariably causes metabolic changes in the infected cell and several
types of host cells that respond to the infection. Among metabolic changes, the most …
types of host cells that respond to the infection. Among metabolic changes, the most …
Molecular targeted therapies in glioblastoma multiforme: a systematic overview of global trends and findings
This systematic review assesses current molecular targeted therapies for glioblastoma
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …
Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …
PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition
Z Gao, J Xu, Y Fan, Y Qi, S Wang, S Zhao… - Journal of Experimental …, 2022 - Springer
Background Resistance to temozolomide (TMZ) is a major obstacle to preventing
glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) …
glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) …
Natural compounds as promising adjuvant agents in the treatment of gliomas
In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually,
glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid …
glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid …