Abstract In men>~ 35 years, aging is associated with perturbations in the hypothalamus-
pituitary–testicular axis and declining serum testosterone concentrations. The major …

Polycystic ovary syndrome (PCOS) affects up to 20% of women but remains poorly
understood. It is a heterogeneous condition with many potential comorbidities. This review …

Gonadotropin-releasing hormone (GnRH) is the final output of the central nervous system
that drives fertility. A characteristic of GnRH secretion is its pulsatility, which is driven by a …

Gonadotropin-releasing hormone (GnRH)-synthesizing neurons orchestrate reproduction
centrally. Early studies have proposed the contribution of acetylcholine (ACh) to …

After the discovery of GnRH, GnRH neurons have been considered to represent the final
common pathway for the neural control of reproduction. There is now compelling data in …

Non-sensory neurons in the mammalian brain possess a primary cilium. Neuronal cilia act
as antenna and receive inputs from the extracellular environment to modulate …

The hypothalamus is an important regulator of autonomic and endocrine functions also
involved in aging regulation. The aging process in the hypothalamus is accompanied by …

The reproductive neuropeptide kisspeptin has emerged as the master regulator of
mammalian reproduction due to its key roles in the initiation of puberty and the control of …

Central precocious puberty (СPP) is caused by premature reactivation of the hypothalamic–
pituitary–gonadal axis. Genetic, epigenetic, and environmental factors play a crucial role in …

The market for technology that tracks ovulation to promote conception is rapidly expanding
in the United States, targeting the growing audience of technologically proficient …