The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Ethnopharmacological relevance Evodia rutaecarpa, a well-known herb medicine in China,
is extensively applied in traditional Chinese medicine (TCM). The plant has the effects of …

Since the antitumor activity of cisplatin was discovered in 1967 by Rosenberg, platinum-
based anticancer drugs have played an important role in chemotherapy in clinic …

The molecular hybridization of different compounds with known pharmacological activity is a
particularly prominent approach for the design of potential drugs with improved …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …

Herein, a new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4 H-pyrazol-3-yl) acetamide
derivatives containing 1, 3, 4-thiadiazole (10a–i) and 4 H-1, 2, 4-triazol-4-amine (11a–r) …

Alkaloids, a category of natural products with ring structures and nitrogen atoms, include
most US Food and Drug Administration approved plant derived anti-cancer agents …

The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …

Besides worthy development in cancer therapy, cancer is still one of the leading causes of
death, worldwide. The future burden of cancer will probably be even larger because people …

Current trends and characteristic examples of recent advances in syntheses of practically
important compounds bearing semi-polar nitrogen–oxygen bonds (NO-systems) are …