[HTML][HTML] Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness …

HE Marei, A Hasan, G Pozzoli, C Cenciarelli - Cancer cell international, 2023 - Springer
Cancer is still the leading cause of death globally. The approval of the therapeutic use of
monoclonal antibodies against immune checkpoint molecules, notably those that target the …

Immune checkpoint inhibitor resistance in hepatocellular carcinoma

Z Wang, Y Wang, P Gao, J Ding - Cancer letters, 2023 - Elsevier
The application of immune checkpoint inhibitors (ICIs) has markedly enhanced the treatment
of hepatocellular carcinoma (HCC), and HCC patients who respond to ICIs have shown …

[HTML][HTML] Radiation combined with immune checkpoint inhibitors for unresectable locally advanced non-small cell lung cancer: synergistic mechanisms, current state …

L Wu, Z Zhang, M Bai, Y Yan, J Yu, Y Xu - Cell Communication and …, 2023 - Springer
Until the advent of immune checkpoint inhibitors (ICIs), definitive radiotherapy (RT)
concurrently with chemotherapy was recommended for unresectable, locally advanced non …

[HTML][HTML] Tumor mutation burden in the prognosis and response of lung cancer patients to immune-checkpoint inhibition therapies

P Vryza, T Fischer, E Mistakidi, A Zaravinos - Translational Oncology, 2023 - Elsevier
Immune checkpoint inhibition (ICI) therapies have reshaped the therapeutic landscape in
lung cancer management, providing first-time improvements in patient response, prognosis …

[HTML][HTML] DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress

X Lin, Y Liu, H Zhang, L Wu, Q Li, J Deng… - Cancer Cell …, 2023 - Springer
Lung cancer is a leading cause of cancer-related deaths, and the most common type is lung
adenocarcinoma (LUAD). LUAD is frequently diagnosed in people who never smoked …

[HTML][HTML] Single-cell mass cytometric analysis of peripheral immunity and multiplex plasma marker profiling of non-small cell lung cancer patients receiving PD-1 …

P Neuperger, K Szalontai, N Gémes, JÁ Balog… - Frontiers in …, 2023 - frontiersin.org
Introduction The effect of platinum-based chemotherapy (Chem.) and second-or multiple-
line immune checkpoint PD-1 blocking therapy by Nivolumab or Pembrolizumab (ICI) was …

Osimertinib after Chemoradiotherapy in Stage III EGFR-Mutated NSCLC

S Lu, T Kato, X Dong, MJ Ahn, LV Quang… - … England Journal of …, 2024 - Mass Medical Soc
Background Osimertinib is a recommended treatment for advanced non–small-cell lung
cancer (NSCLC) with an epidermal growth factor receptor (EGFR) mutation and as adjuvant …

[HTML][HTML] Frontiers of ovarian carcinosarcoma

A Ismail, S Choi, S Boussios - Current treatment options in oncology, 2023 - Springer
Opinion statement Ovarian carcinosarcoma (OCS), also known as a malignant mixed
Müllerian tumour (MMMT), is a rare and aggressive form of cancer that accounts for less …

Tumor-associated neutrophils upregulate PANoptosis to foster an immunosuppressive microenvironment of non-small cell lung cancer

Q Hu, R Wang, J Zhang, Q Xue, B Ding - Cancer Immunology …, 2023 - Springer
Tumor microenvironment (TME) cells orchestrate an immunosuppressive milieu that
supports cancer cell proliferation. Tumor-associated neutrophils (TANs) have gained …

[HTML][HTML] Innate and adaptive responses of intratumoral immunotherapy with endosomal toll-like receptor agonists

FT Andón, S Leon, A Ummarino, E Redin, P Allavena… - Biomedicines, 2022 - mdpi.com
Toll-like receptors (TLRs) are natural initial triggers of innate and adaptive immune
responses. With the advent of cancer immunotherapy, nucleic acids engineered as ligands …