[HTML][HTML] Metastatic prostate cancer remains incurable, why?
L Dong, RC Zieren, W Xue, TM de Reijke… - Asian journal of urology, 2019 - Elsevier
Metastatic prostate cancer patients present in two ways—with already disseminated disease
at the time of presentation or with disease recurrence after definitive local therapy. Androgen …
at the time of presentation or with disease recurrence after definitive local therapy. Androgen …
Mechanisms of enzalutamide resistance in castration‐resistant prostate cancer and therapeutic strategies to overcome it
Y Wang, J Chen, Z Wu, W Ding, S Gao… - British journal of …, 2021 - Wiley Online Library
Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …
therapy is the first‐line therapy. However, most cases will eventually develop castration …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
Discovery of ARD-69 as a highly potent proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) for the treatment of prostate cancer
We report herein the discovery of highly potent PROTAC degraders of androgen receptor
(AR), as exemplified by compound 34 (ARD-69). ARD-69 induces degradation of AR protein …
(AR), as exemplified by compound 34 (ARD-69). ARD-69 induces degradation of AR protein …
Strategies toward discovery of potent and orally bioavailable proteolysis targeting chimera degraders of androgen receptor for the treatment of prostate cancer
Proteolysis targeting chimera (PROTAC) small-molecule degraders have emerged as a
promising new type of therapeutic agents, but the design of PROTAC degraders with …
promising new type of therapeutic agents, but the design of PROTAC degraders with …
Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance
The androgen receptor (AR) antagonist enzalutamide is one of the principal treatments for
men with castration-resistant prostate cancer (CRPC). However, not all patients respond …
men with castration-resistant prostate cancer (CRPC). However, not all patients respond …
[HTML][HTML] Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity
TC Westbrook, X Guan, E Rodansky, D Flores… - Nature …, 2022 - nature.com
The androgen receptor (AR) signaling inhibitor enzalutamide (enza) is one of the principal
treatments for metastatic castration-resistant prostate cancer (CRPC). Several emergent …
treatments for metastatic castration-resistant prostate cancer (CRPC). Several emergent …
[HTML][HTML] Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside
Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …
also participates in the development and progression of cancer. In recent decades …
A comprehensive overview of small-molecule androgen receptor degraders: Recent progress and future perspectives
S Ha, G Luo, H Xiang - Journal of Medicinal Chemistry, 2022 - ACS Publications
Prostate cancer (PC), the second most prevalent malignancy in men worldwide, has been
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …
The FGF/FGFR system in the physiopathology of the prostate gland
Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or
endocrine functions in a variety of biological processes, including embryonic development …
endocrine functions in a variety of biological processes, including embryonic development …