[PDF][PDF] Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications

P Caravan, JJ Ellison, TJ McMurry… - Chemical …, 1999 - s.mriquestions.com
Gadolinium, an obscure lanthanide element buried in the middle of the periodic table, has in
the course of a decade become commonplace in medical diagnostics. Like platinum in …

Nano-sized MRI contrast agents with dendrimer cores

H Kobayashi, MW Brechbiel - Advanced drug delivery reviews, 2005 - Elsevier
Gadolinium-based MRI contrast agents (CAs) can be effective at a∼ 100-fold lower
concentration of Gadolinium ions in comparison to the concentration of Iodine atoms …

The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates

P Caravan, NJ Cloutier, MT Greenfield… - Journal of the …, 2002 - ACS Publications
MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently
undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to …

Dendrimer-based macromolecular MRI contrast agents: characteristics and application

H Kobayashi, MW Brechbiel - Molecular imaging, 2003 - journals.sagepub.com
Numerous macromolecular MRI contrast agents prepared employing relatively simple
chemistry may be readily available that can provide sufficient enhancement for multiple …

Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies

L Jia, D Zhang, Z Li, C Duan, Y Wang, F Feng… - Colloids and Surfaces B …, 2010 - Elsevier
The objective of the present study was to explore the potential of nanostructured lipid
carriers (NLCs) for the intravenous delivery of silybin, a poorly water-soluble …

Relaxivity of gadolinium (III) complexes: theory and mechanism

E Toth, L Helm, A Merbach - The chemistry of contrast agents in …, 2013 - Wiley Online Library
The aim of using a contrast agent in Magnetic Resonance Imaging is to accelerate the
relaxation of water protons in the surrounding tissue. Gadolinium (Gd)(III) complexes are far …

Delivery of diagnostic agents for magnetic resonance imaging

Y Okuhata - Advanced drug delivery reviews, 1999 - Elsevier
A review of contrast agents used for magnetic resonance imaging was made with regard to
methods of drug delivery using published literature. Since the clinical approval of Gd-DTPA …

Dendrimer-based nanosized MRI contrast agents

H Kobayashi, MW Brechbiel - Current pharmaceutical …, 2004 - ingentaconnect.com
Paramagnetic metals can induce T1 shortening by interaction with free water molecules.
Two metal ions, Gadolinium and Manganese, are currently available for human use …

Gadolinium (III)-based blood-pool contrast agents for magnetic resonance imaging: status and clinical potential

AM Mohs, ZR Lu - Expert opinion on drug delivery, 2007 - Taylor & Francis
Blood-pool MRI contrast agents have enormous potential to aid sensitive magnetic
resonance detection and yield definitive diagnostic data of cancer and diseases of the …

Gd nanoparticulates: from magnetic resonance imaging to neutron capture therapy

P Sharma, SC Brown, G Walter, S Santra… - Advanced Powder …, 2007 - Elsevier
Gadolinium (Gd) chelates have been extensively applied to enhance the imagery of
anatomical tissues via magnetic resonance imaging (MRI). These molecular complexes …