The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

A combination of extrinsic (passive) and intrinsic (active) forces move lymph against a
hydrostatic pressure gradient in most regions of the body. The effectiveness of the lymph …

Pressure-dependent chronotropy of murine lymphatic collecting vessels relies on the
activation of the Ca2+-activated chloride channel encoded by Anoctamin 1 (Ano1) in …

Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

The ability of cells to sense and respond to physical forces has been recognized for
decades, but researchers are only beginning to appreciate the fundamental importance of …

KATP channels function as negative regulators of active lymphatic pumping and lymph
transport. This review summarizes and critiques the evidence for the expression of specific …

Lymphatic vessel networks are a main part of the vertebrate cardiovascular system, which
participate in various physiological and pathological processes via regulation of fluid …

Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of
people worldwide. Due to its critical role in the process of inflammation, a dysfunctional …

We identified a regional dichotomy in murine lymphatic contractile function with regard to
vessel location within the periphery or visceral cavity. All vessels isolated from peripheral …

Obesity and metabolic syndrome pose a significant risk for developing cardiovascular
disease and remain a critical healthcare challenge. Given the lymphatic system's role as a …