Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods
S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
Artificial biocatalytic linear cascades for preparation of organic molecules
JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …
A cascade is defined as the combination of at least two reaction steps in a single reaction …
Recent advances in biotechnological applications of alcohol dehydrogenases
YG Zheng, HH Yin, DF Yu, X Chen, XL Tang… - Applied microbiology …, 2017 - Springer
Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze
the interconversion between alcohols and aldehydes or ketones with high stereoselectivity …
the interconversion between alcohols and aldehydes or ketones with high stereoselectivity …
[PDF][PDF] How Green is Biocatalysis? To Calculate is To Know.
Green chemistry aims to minimize the environmental hazards of chemical processes and
their products. Ever since its introduction by Anastas,[1] this principle has inspired …
their products. Ever since its introduction by Anastas,[1] this principle has inspired …
Biocatalytic ketone reduction: a green and efficient access to enantiopure alcohols
Y Ni, JH Xu - Biotechnology advances, 2012 - Elsevier
Chiral secondary alcohols play an important role in pharmaceutical, agrochemical, and
chemical industries. In recent years, impressive steps forward have been achieved towards …
chemical industries. In recent years, impressive steps forward have been achieved towards …
Enzymatic cofactor regeneration systems: A new perspective on efficiency assessment
Nowadays, the specificity of enzymatic processes makes them more and more important
every year, and their usage on an industrial scale seems to be necessary. Enzymatic …
every year, and their usage on an industrial scale seems to be necessary. Enzymatic …
Light‐driven kinetic resolution of α‐functionalized carboxylic acids enabled by an engineered fatty acid photodecarboxylase
J Xu, Y Hu, J Fan, M Arkin, D Li, Y Peng… - Angewandte Chemie …, 2019 - Wiley Online Library
Chiral α‐functionalized carboxylic acids are valuable precursors for a variety of medicines
and natural products. Herein, we described an engineered fatty acid photodecarboxylase …
and natural products. Herein, we described an engineered fatty acid photodecarboxylase …
Biocatalytic valorization of biobased 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furfurylamine in a three-constituent deep eutectic solvent–water system
Z Wang, H Chai, J Ren, Y Tao, Q Li, C Ma… - ACS Sustainable …, 2022 - ACS Publications
5-Hydroxymethyl-2-furfurylamine (HMFA), as an important 5-hydroxymethylfurfural (5-HMF)
derivative, has many potential applications in the preparation of diuretics, antihypertensive …
derivative, has many potential applications in the preparation of diuretics, antihypertensive …
New opportunities for biocatalysis: driving the synthesis of chiral chemicals
GW Zheng, JH Xu - Current opinion in biotechnology, 2011 - Elsevier
Various biocatalytic methods have been developed for the synthesis of chiral chemicals,
which have made their synthesis more environmentally friendly and product-specific. New …
which have made their synthesis more environmentally friendly and product-specific. New …
Efficient chemoenzymatic valorization of biobased D-fructose into 2, 5-bis (hydroxymethyl) furan with deep eutectic solvent Lactic acid: Betaine and Pseudomonas …
S Zhang, C Ma, Q Li, Q Li, YC He - Bioresource Technology, 2022 - Elsevier
Bis (hydroxymethyl) furan (BHMF) is one kind of important upgraded derivatives of biobased
5-hydroxymethylfuran (5-HMF). This study verified the feasibility of one-pot chemoenzymatic …
5-hydroxymethylfuran (5-HMF). This study verified the feasibility of one-pot chemoenzymatic …