Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Recent advances in biotechnological applications of alcohol dehydrogenases

YG Zheng, HH Yin, DF Yu, X Chen, XL Tang… - Applied microbiology …, 2017 - Springer
Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze
the interconversion between alcohols and aldehydes or ketones with high stereoselectivity …

[PDF][PDF] How Green is Biocatalysis? To Calculate is To Know.

Y Ni, D Holtmann, F Hollmann - ChemCatChem, 2014 - researchgate.net
Green chemistry aims to minimize the environmental hazards of chemical processes and
their products. Ever since its introduction by Anastas,[1] this principle has inspired …

Biocatalytic ketone reduction: a green and efficient access to enantiopure alcohols

Y Ni, JH Xu - Biotechnology advances, 2012 - Elsevier
Chiral secondary alcohols play an important role in pharmaceutical, agrochemical, and
chemical industries. In recent years, impressive steps forward have been achieved towards …

Enzymatic cofactor regeneration systems: A new perspective on efficiency assessment

K Bachosz, J Zdarta, M Bilal, AS Meyer… - Science of The Total …, 2023 - Elsevier
Nowadays, the specificity of enzymatic processes makes them more and more important
every year, and their usage on an industrial scale seems to be necessary. Enzymatic …

Light‐driven kinetic resolution of α‐functionalized carboxylic acids enabled by an engineered fatty acid photodecarboxylase

J Xu, Y Hu, J Fan, M Arkin, D Li, Y Peng… - Angewandte Chemie …, 2019 - Wiley Online Library
Chiral α‐functionalized carboxylic acids are valuable precursors for a variety of medicines
and natural products. Herein, we described an engineered fatty acid photodecarboxylase …

Biocatalytic valorization of biobased 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furfurylamine in a three-constituent deep eutectic solvent–water system

Z Wang, H Chai, J Ren, Y Tao, Q Li, C Ma… - ACS Sustainable …, 2022 - ACS Publications
5-Hydroxymethyl-2-furfurylamine (HMFA), as an important 5-hydroxymethylfurfural (5-HMF)
derivative, has many potential applications in the preparation of diuretics, antihypertensive …

New opportunities for biocatalysis: driving the synthesis of chiral chemicals

GW Zheng, JH Xu - Current opinion in biotechnology, 2011 - Elsevier
Various biocatalytic methods have been developed for the synthesis of chiral chemicals,
which have made their synthesis more environmentally friendly and product-specific. New …

Efficient chemoenzymatic valorization of biobased D-fructose into 2, 5-bis (hydroxymethyl) furan with deep eutectic solvent Lactic acid: Betaine and Pseudomonas …

S Zhang, C Ma, Q Li, Q Li, YC He - Bioresource Technology, 2022 - Elsevier
Bis (hydroxymethyl) furan (BHMF) is one kind of important upgraded derivatives of biobased
5-hydroxymethylfuran (5-HMF). This study verified the feasibility of one-pot chemoenzymatic …