Drug-induced gene expression profiling provides a lot of useful information covering various
aspects of drug discovery and development. Most importantly, this knowledge can be used …

Breast cancer is the most prevalent non-skin cancer diagnosed in females and developing
novel therapeutic strategies to improve patient outcomes is crucial. The immune system …

Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin
found in green plants and a minimum content of an organotin (IV) fragment (1-MSN-Sn, 2 …

Breast cancer continues to be the most diagnosed cancer among women worldwide.
Neoadjuvant chemotherapy is the standard of care for breast cancer patients with locally …

Background: Immune checkpoint inhibitors (ICIs) have been an emerging treatment strategy
for advanced triple-negative breast cancer (TNBC). Some studies have shown that high …

Abstract Purpose: Both EGFR and PI3K-Akt signaling pathways have been used as
therapeutically actionable targets, but resistance is frequently reported. In this report, we …

Calorie restriction (CR), referred to as a reduction in dietary calorie intake without
malnutrition, has been demonstrated to be a safe way to extend longevity of yeast, worms …

Background: The non-receptor protein tyrosine phosphatase (PTPN) gene family has been
considered to be involved in the oncogenesis and development of multiple cancers …

Combination immunotherapy has emerged as a promising strategy to address the
challenges associated with immune checkpoint inhibitor (ICI) therapy in breast cancer. The …

Oncogenic microRNA (miRNA), especially miRNA-21 upregulation in triple-negative breast
cancer (TNBC), suggests a new class of therapeutic targets. In this study, we aimed to create …