Amygdala and bed nucleus of the stria terminalis circuitry: implications for addiction-related behaviors

AM Stamatakis, DR Sparta, JH Jennings… - …, 2014 - Elsevier
Complex motivated behavioral processes, such as those that can go awry following
substance abuse and other neuropsychiatric disorders, are mediated by a distributive …

The intersection of stress and reward: BNST modulation of aversive and appetitive states

S Ch'ng, J Fu, RM Brown, SJ McDougall… - Progress in Neuro …, 2018 - Elsevier
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …

Diverging neural pathways assemble a behavioural state from separable features in anxiety

SY Kim, A Adhikari, SY Lee, JH Marshel, CK Kim… - Nature, 2013 - nature.com
Behavioural states in mammals, such as the anxious state, are characterized by several
features that are coordinately regulated by diverse nervous system outputs, ranging from …

Noradrenergic circuits and signaling in substance use disorders

AM Downs, ZA McElligott - Neuropharmacology, 2022 - Elsevier
The central noradrenergic system innervates almost all regions of the brain and, as such, is
well positioned to modulate many neural circuits implicated in behaviors and physiology …

Regulation of cocaine-related behaviours by estrogen and progesterone

DR Peart, AK Andrade, CN Logan… - Neuroscience & …, 2022 - Elsevier
Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …

The bed nucleus of the stria terminalis in drug-associated behavior and affect: a circuit-based perspective

O Vranjkovic, M Pina, TL Kash, DG Winder - Neuropharmacology, 2017 - Elsevier
The bed nucleus of the stria terminalis was first described nearly a century ago and has
since emerged as a region central to motivated behavior and affective states. The last …

Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward

Y Silberman, DG Winder - Frontiers in psychiatry, 2013 - frontiersin.org
Stress and anxiety play an important role in the development and maintenance of drug and
alcohol addiction. The bed nucleus of the stria terminalis (BNST), a brain region involved in …

[PDF][PDF] An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement

G Tian, M Hui, D Macchia, P Derdeyn, A Rogers… - Cell reports, 2022 - cell.com
Although midbrain dopamine (DA) circuits are central to motivated behaviors, our
knowledge of how experience modifies these circuits to facilitate subsequent behavioral …

Chronic intermittent ethanol exposure dysregulates a GABAergic microcircuit in the bed nucleus of the stria terminalis

D Pati, CA Marcinkiewcz, JF DiBerto, ES Cogan… - …, 2020 - Elsevier
Neuroadaptations in brain regions that regulate emotional and reward-seeking behaviors
have been suggested to contribute to pathological behaviors associated with alcohol-use …

Stress-induced cocaine seeking requires a beta-2 adrenergic receptor-regulated pathway from the ventral bed nucleus of the stria terminalis that regulates CRF …

O Vranjkovic, PJ Gasser, CH Gerndt… - Journal of …, 2014 - Soc Neuroscience
The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-
induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor …