Measuring cerebrovascular reactivity: what stimulus to use?

J Fierstra, O Sobczyk… - The Journal of …, 2013 - Wiley Online Library
Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory
or vasoconstrictive stimulus. Measuring variations of cerebrovascular reactivity between …

Convective oxygen transport and fatigue

M Amann, JAL Calbet - Journal of applied physiology, 2008 - journals.physiology.org
During exercise, fatigue is defined as a reversible reduction in force-or power-generating
capacity and can be elicited by “central” and/or “peripheral” mechanisms. During skeletal …

Prospective targeting and control of end‐tidal CO2 and O2 concentrations

M Slessarev, J Han, A Mardimae… - The Journal of …, 2007 - Wiley Online Library
Current methods of forcing end‐tidal PCO2 (PETCO2) and PO2 (PETO2) rely on breath‐by‐
breath adjustment of inspired gas concentrations using feedback loop algorithms. Such …

Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals

KM Sicard, TQ Duong - Neuroimage, 2005 - Elsevier
Functional magnetic resonance imaging (fMRI) was used to investigate the effects of
inspired hypoxic, hyperoxic, and hypercapnic gases on baseline and stimulus-evoked …

Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans

K Ide, M Eliasziw, MJ Poulin - Journal of applied physiology, 2003 - journals.physiology.org
This study examined the relationship between cerebral blood flow (CBF) and end-tidal Pco2
(PetCO2) in humans. We used transcranial Doppler ultrasound to determine middle cerebral …

Variability of physiological brain perfusion in healthy subjects–A systematic review of modifiers. Considerations for multi-center ASL studies

P Clement, HJ Mutsaerts, L Václavů… - Journal of Cerebral …, 2018 - journals.sagepub.com
Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: regulation by carbon dioxide

PN Ainslie, MJ Poulin - Journal of applied physiology, 2004 - journals.physiology.org
This study examined the effect of high, normal, and uncontrolled end-tidal Pco2 (PetCO2) on
the ventilatory, peak cerebral blood flow velocity (V̄ p), and mean arterial blood pressure …

Relationship between oxidative stress and HIF-1α mRNA during sustained hypoxia in humans

V Pialoux, R Mounier, AD Brown, CD Steinback… - Free Radical Biology …, 2009 - Elsevier
The aim of this study was to investigate the relations among reactive oxygen species (ROS),
hypoxia inducible factor (HIF-1α) gene expression, HIF-1α target gene erythropoietin (EPO) …

Ventilatory and cerebrovascular regulation and integration at high-altitude

RL Hoiland, CA Howe, GB Coombs… - Clinical Autonomic …, 2018 - Springer
Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

Measuring the ventilatory response to hypoxia

J Duffin - The Journal of physiology, 2007 - Wiley Online Library
After defining the current approach to measuring the hypoxic ventilatory response this paper
explains why this method is not appropriate for comparisons between individuals or …