Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …

Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …

Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular,
skeletal, and central nervous systems. In this report, we review the literature in both rodents …

Many cancer patients suffer from severe fatigue when treated with chemotherapy or
radiotherapy; however, the etiology and pathogenesis of this kind of fatigue remains …

Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

The incidence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic
proportions. The pathophysiology of T2DM is complex and involves insulin resistance …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

With the steady rise in the prevalence of obesity and its associated diseases, research
aimed at understanding the mechanisms that regulate and control whole body energy …

Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in
a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can …