The increasing prevalence of obesity worldwide has imparted renewed impetus to the study
of the mechanisms of appetite regulation. Digestion and nutrient absorption take place in the …

Recent research has convincingly demonstrated a bidirectional communication axis
between the gut and liver that enables the gut microbiota to strongly affect animals' feeding …

When challenged with a variety of inflammatory threats, multiple systems across the body
undergo physiological responses to promote defense and survival. The constellation of …

The hypothalamus plays a critical role in the regulation of food intake and body weight, and
recent work has defined a core circuitry in the hypothalamus that appears to mediate many …

BACKGROUND & AIMS: Mechanisms underlying weight loss maintenance after gastric
bypass are poorly understood. Our aim was to examine the effects of gastric bypass on …

Despite an alarming increase in the burden of obesity worldwide, body adiposity seems to
be a regulated physiological variable. Regulation of adiposity occurs through a classical …

Estrogens regulate key features of metabolism, including food intake, body weight, energy
expenditure, insulin sensitivity, leptin sensitivity, and body fat distribution. There are two …

Maintenance of energy balance requires regulation of the amount and timing of food intake.
Decades of experiments utilizing pharmacological and later genetic manipulations have …

Chronic diseases such as type 2 diabetes and cardiovascular disease are the leading cause
of death and disability worldwide. Although the metabolic syndrome has been defined in …

A considerable body of evidence links diminished brain-derived neurotrophic factor (BDNF)
signaling to energy balance dysregulation and severe obesity in humans and rodents …