New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

Cytoplasmic functions of long noncoding RNAs

JH Noh, KM Kim, WG McClusky… - Wiley …, 2018 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found
throughout the cell that lack protein‐coding function. Their functions are closely linked to …

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

K Abdelmohsen, AC Panda, R Munk… - RNA biology, 2017 - Taylor & Francis
HuR influences gene expression programs and hence cellular phenotypes by binding to
hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular …

[HTML][HTML] RNA-binding proteins in cancer: functional and therapeutic perspectives

D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …

[HTML][HTML] CircSMARCA5 regulates VEGFA mRNA splicing and angiogenesis in glioblastoma multiforme through the binding of SRSF1

D Barbagallo, A Caponnetto, D Brex, F Mirabella… - Cancers, 2019 - mdpi.com
Circular RNAs are a large group of RNAs whose cellular functions are still being
investigated. We recently proposed that circSMARCA5 acts as sponge for the splicing factor …

Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer

Y Lan, X Xiao, Z He, Y Luo, C Wu, L Li… - Nucleic acids …, 2018 - academic.oup.com
Overexpressed in colon carcinoma-1 (OCC-1) is one of the earliest annotated long
noncoding RNAs (lncRNAs) in colorectal cancer (CRC); however, its function remains …

[HTML][HTML] The regulation of protein translation and its implications for cancer

P Song, F Yang, H Jin, X Wang - Signal transduction and targeted …, 2021 - nature.com
In addition to the deregulation of gene transcriptions and post-translational protein
modifications, the aberrant translation from mRNAs to proteins plays an important role in the …

[HTML][HTML] LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

A Li, R Peng, Y Sun, H Liu, H Peng, Z Zhang - Cell death & disease, 2018 - nature.com
Long intergenic noncoding RNAs (lincRNAs) have been gradually identified to be functional
in a variety of different mechanisms associating with development and epigenetic regulation …

[HTML][HTML] IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives

C Mancarella, K Scotlandi - Frontiers in cell and developmental …, 2020 - frontiersin.org
RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

[HTML][HTML] The role of lncRNAs in gene expression regulation through mRNA stabilization

M Sebastian-delaCruz, I Gonzalez-Moro… - Non-coding RNA, 2021 - mdpi.com
mRNA stability influences gene expression and translation in almost all living organisms,
and the levels of mRNA molecules in the cell are determined by a balance between …