[HTML][HTML] Exosomal composition, biogenesis and profiling using point-of-care diagnostics—implications for cardiovascular disease

D Burtenshaw, B Regan, K Owen, D Collins… - Frontiers in cell and …, 2022 - frontiersin.org
Arteriosclerosis is an important age-dependent disease that encompasses atherosclerosis,
in-stent restenosis (ISR), pulmonary hypertension, autologous bypass grafting and …

Extracellular vesicles in vascular remodeling

C Ye, F Zheng, N Wu, G Zhu, X Li - Acta Pharmacologica Sinica, 2022 - nature.com
Vascular remodeling contributes to the development of a variety of vascular diseases
including hypertension and atherosclerosis. Phenotypic transformation of vascular cells …

Two-faced Janus: the dual role of macrophages in atherosclerotic calcification

OJ Waring, NT Skenteris, EAL Biessen… - Cardiovascular …, 2022 - academic.oup.com
Calcification is an independent predictor of atherosclerosis-related cardiovascular events.
Microcalcification is linked to inflamed, unstable lesions, in comparison to the fibrotic stable …

[HTML][HTML] The interplay between brain vascular calcification and microglia

U Maheshwari, SF Huang, S Sridhar… - Frontiers in Aging …, 2022 - frontiersin.org
Vascular calcifications are characterized by the ectopic deposition of calcium and phosphate
in the vascular lumen or wall. They are a common finding in computed tomography scans or …

[HTML][HTML] MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling

HY Chiang, PH Chu, SC Chen, TH Lee - Communications Biology, 2022 - nature.com
Vascular calcification occurs in arterial aging, atherosclerosis, diabetes mellitus, and chronic
kidney disease. Transforming growth factor-β1 (TGF-β1) is a key modulator driving the …

Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis

C Chen, Y Li, H Lu, K Liu, W Jiang… - Experimental …, 2022 - journals.sagepub.com
Vascular calcification (VC) is the most widespread pathological change in diseases of the
vascular system. However, we do not have a good understanding of the molecular …

TNFα activation and TGFβ blockage act synergistically for smooth muscle cell calcification in patients with venous thrombosis via TGFβ/ERK pathway

P Wang, Y Pan, C Yang, L Zhang… - Journal of Cellular …, 2022 - Wiley Online Library
Venous calcification has been observed in post‐thrombotic syndrome (PTS) patients; yet,
the cell types and possible mechanisms regulating this process are still unclear. We …

[HTML][HTML] Hypoxic culture maintains cell growth of the primary human valve interstitial cells with stemness

K Kanno, T Sakaue, M Hamaguchi… - International Journal of …, 2021 - mdpi.com
The characterization of aortic valve interstitial cells (VICs) cultured under optimal conditions
is essential for understanding the molecular mechanisms underlying aortic valve stenosis …

miR-33a-5p suppresses ox-LDL-stimulated calcification of vascular smooth muscle cells by targeting METTL3

R Han, J Luo, L Wang, L Li, H Zheng - Cardiovascular Toxicology, 2021 - Springer
Oxidized low-density lipoprotein (ox-LDL) accumulation in the vascular wall plays a pivotal
role in the development of atherosclerosis and vascular calcification. However, few studies …

[HTML][HTML] Association between low-density lipoprotein cholesterol and vascular biomarkers in primary prevention

M Kozakova, C Morizzo, G Jamagidze, D Della Latta… - Biomedicines, 2023 - mdpi.com
Several noninvasive vascular biomarkers have been proposed to improve risk stratification
for atherothrombotic events. To identify biomarkers suitable for detecting intermediate-risk …