Abstract Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments
(DMTs) must both limit unwanted immune responses associated with disease initiation and …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS) manifested with varying clinical course, pathology, and inflammatory patterns …

Experimental autoimmune encephalomyelitis (EAE) is still the most widely accepted animal
model of multiple sclerosis (MS). Different types of EAE have been developed in order to …

Psoriasis is strongly associated with streptococcal throat infection, and patients have
increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T …

Vitamin D is a steroid hormone that is acquired via diet or synthesized in the skin upon UV
exposure and needs subsequent hydroxylation steps to become activated as 1, 25 …

Myelin presentation to T cells in the central nervous system (CNS) sustains inflammation in
multiple sclerosis (MS). CD4+ and CD8+ T cells contribute to MS, but only cells that present …

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system, in which the myelin sheath has been considered to be the primary target for …

The contribution of local factors to the activation of immune cells infiltrating the CNS of
patients with multiple sclerosis (MS) remains to be defined. The cytokine IL-15 is pivotal in …

Cytotoxic CD8+ T cells are increasingly recognized as key players in various inflammatory
and degenerative central nervous system (CNS) disorders. CD8+ T cells are believed to …