Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
Update on the 22q11. 2 deletion syndrome and its relevance to schizophrenia
L Van, E Boot, AS Bassett - Current opinion in psychiatry, 2017 - journals.lww.com
Progress in characterizing and predicting psychotic illness in 22q11. 2DS supports this
identifiable subpopulation as a molecular model with important implications for …
identifiable subpopulation as a molecular model with important implications for …
Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including
Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome …
Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome …
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11. 2 duplication syndrome by genetic correction of an epilepsy network hub
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological
basis of shared risk remains poorly understood. The 16p11. 2 duplication is a copy number …
basis of shared risk remains poorly understood. The 16p11. 2 duplication is a copy number …
Intellectual disability: dendritic anomalies and emerging genetic perspectives
Intellectual disability (ID) corresponds to several neurodevelopmental disorders of
heterogeneous origin in which cognitive deficits are commonly associated with …
heterogeneous origin in which cognitive deficits are commonly associated with …
Systems analysis of the 22q11. 2 microdeletion syndrome converges on a mitochondrial interactome necessary for synapse function and behavior
A Gokhale, C Hartwig, AAH Freeman… - Journal of …, 2019 - Soc Neuroscience
Neurodevelopmental disorders offer insight into synaptic mechanisms. To unbiasedly
uncover these mechanisms, we studied the 22q11. 2 syndrome, a recurrent copy number …
uncover these mechanisms, we studied the 22q11. 2 syndrome, a recurrent copy number …
MZB1 targeted by miR‐185‐5p inhibits the migration of human periodontal ligament cells through NF‐κB signaling and promotes alveolar bone loss
D Li, Y Zhu, L Zhang, L Shi, L Deng… - Journal of …, 2022 - Wiley Online Library
Objective To explore the role of Marginal Zone B and B‐1 Cell‐Specific Protein (MZB1), a
novel molecule associated with periodontitis, in migration of human periodontal ligament …
novel molecule associated with periodontitis, in migration of human periodontal ligament …
A mouse model of 22q11. 2 deletions: molecular and behavioral signatures of Parkinson's disease and schizophrenia
A Sumitomo, K Horike, K Hirai, N Butcher, E Boot… - Science …, 2018 - science.org
Individuals with chromosome 22q11. 2 deletions are at increased risk of developing
psychiatric conditions, most notably, schizophrenia (SZ). Recently, clinical studies have also …
psychiatric conditions, most notably, schizophrenia (SZ). Recently, clinical studies have also …
22q11. 2 deletion syndrome–associated Parkinson's disease
E Boot, AS Bassett, C Marras - Movement disorders clinical …, 2019 - Wiley Online Library
Abstract Background 22q11. 2 deletion syndrome (22q11. 2DS) is a multisystem condition
associated with an increased risk of early‐onset Parkinson's disease (PD). Methods We …
associated with an increased risk of early‐onset Parkinson's disease (PD). Methods We …
Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11. 2 deletion syndrome
M Zafarullah, K Angkustsiri, A Quach, S Yeo… - Metabolomics, 2024 - Springer
Abstract Introduction The chromosome 22q11. 2 deletion syndrome (22q11. 2DS) is
characterized by a well-defined microdeletion and is associated with a wide range of brain …
characterized by a well-defined microdeletion and is associated with a wide range of brain …