An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
Human coronavirus: host-pathogen interaction
TS Fung, DX Liu - Annual review of microbiology, 2019 - annualreviews.org
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
[HTML][HTML] Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy
Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …
[HTML][HTML] Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …
Host factors in coronavirus replication
AH De Wilde, EJ Snijder, M Kikkert… - Roles of host gene and …, 2018 - Springer
Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
Membrane binding proteins of coronaviruses
EA J Alsaadi, IM Jones - Future Virology, 2019 - Future Medicine
Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of
severities. Their members include zoonotic viruses with pandemic potential where …
severities. Their members include zoonotic viruses with pandemic potential where …
Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein: from mechanistic studies to clinical trials for COVID-19
An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA
JA Encinar, JA Menendez - Viruses, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …
Nrf2‐interacting nutrients and COVID‐19: time for research to develop adaptation strategies
J Bousquet, JP Cristol, W Czarlewski… - Clinical and …, 2020 - Wiley Online Library
There are large between‐and within‐country variations in COVID‐19 death rates. Some very
low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a …
low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a …