Severe covid-19 pneumonia: pathogenesis and clinical management
AH Attaway, RG Scheraga, A Bhimraj, M Biehl… - bmj, 2021 - bmj.com
Severe covid-19 pneumonia has posed critical challenges for the research and medical
communities. Older age, male sex, and comorbidities increase the risk for severe disease …
communities. Older age, male sex, and comorbidities increase the risk for severe disease …
[HTML][HTML] Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …
has infected more than 46 million people worldwide, killing over one million two hundred …
[HTML][HTML] ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection
A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …
three highly pathogenic variants have emerged in the 21st century. The newest member of …
[HTML][HTML] SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …
[HTML][HTML] A possible role for anti-idiotype antibodies in SARS-CoV-2 infection and vaccination
WJ Murphy, DL Longo - New England Journal of Medicine, 2022 - Mass Medical Soc
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination |
New England Journal of Medicine Skip to main content The New England Journal of …
New England Journal of Medicine Skip to main content The New England Journal of …
Carbon-based nanomaterials: promising antiviral agents to combat COVID-19 in the microbial-resistant era
Therapeutic options for the highly pathogenic human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID …
coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID …
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19: a …
S Florescu, D Stanciu, M Zaharia, A Kosa, D Codreanu… - Jama, 2023 - jamanetwork.com
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor
clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin …
clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin …
An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants
The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry.
Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high …
Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high …