[HTML][HTML] Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes
A Inoue - Current Opinion in Genetics & Development, 2023 - Elsevier
Genomic imprinting is illustrative of intergenerational epigenetic inheritance. The passage of
parental genomes into the embryo is accompanied by epigenetic modifications, resulting in …
parental genomes into the embryo is accompanied by epigenetic modifications, resulting in …
Imprinted genes and the manipulation of parenting in mammals
Genomic imprinting refers to the parent-of-origin expression of genes, which originates from
epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a …
epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a …
Paternal genetic intergenerational and transgenerational effects of cadmium exposure on hormone synthesis disorders in progeny ovarian granulosa cells
Y Sun, C Zhang, L Luo, H Lin, C Liu, W Zhang - Environmental Pollution, 2023 - Elsevier
To investigate the paternal genetic effects of cadmium (Cd) exposure on hormone synthesis
disorders in the ovarian granulosa cells (GCs) of offspring. Here, male Sprague‒Dawley …
disorders in the ovarian granulosa cells (GCs) of offspring. Here, male Sprague‒Dawley …
[HTML][HTML] Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c
A Dimond, M Van de Pette, V Taylor-Bateman… - Scientific Reports, 2023 - nature.com
Genomic imprinting is an epigenetically mediated mechanism that regulates allelic
expression of genes based upon parent-of-origin and provides a paradigm for studying …
expression of genes based upon parent-of-origin and provides a paradigm for studying …
[HTML][HTML] Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker …
C Prodani, EE Irvine, A Sardini, HJ Gleneadie… - Scientific Reports, 2024 - nature.com
We tracked the consequences of in utero protein restriction in mice throughout their
development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c …
development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c …
Legacies of salient environmental experiences—insights from chemosensation
BG Dias - Chemical Senses, 2024 - academic.oup.com
Evidence for parental environments profoundly influencing the physiology, biology, and
neurobiology of future generations has been accumulating in the literature. Recent efforts to …
neurobiology of future generations has been accumulating in the literature. Recent efforts to …
Inheritance of environment-induced phenotypic changes through epigenetic mechanisms
Growing evidence suggests that epigenetic changes through various parental
environmental factors alter the phenotypes of descendants in various organisms …
environmental factors alter the phenotypes of descendants in various organisms …
[HTML][HTML] Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition
HJ Gleneadie, B Fernandez-Ruiz, A Sardini… - Communications …, 2023 - nature.com
Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by loss of function
mutations in the dystrophin gene (Dmd), resulting in progressive muscle weakening. Here …
mutations in the dystrophin gene (Dmd), resulting in progressive muscle weakening. Here …
[HTML][HTML] Bioluminescence imaging of Cyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung
N Veland, HJ Gleneadie, KE Brown, A Sardini… - Communications …, 2024 - nature.com
Aryl hydrocarbon receptor (AHR) signalling integrates biological processes that sense and
respond to environmental, dietary, and metabolic challenges to ensure tissue homeostasis …
respond to environmental, dietary, and metabolic challenges to ensure tissue homeostasis …
[HTML][HTML] Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour
HR Tyson, DJ Harrison, MJ Higgs, AR Isles… - Frontiers in …, 2024 - frontiersin.org
Introduction Imprinted genes are expressed from one parental allele as a consequence of
epigenetic processes initiated in the germline. Consequently, their ability to influence …
epigenetic processes initiated in the germline. Consequently, their ability to influence …