Abstract RNA polymerase II (Pol II)-mediated transcription in eukaryotic cells starts with
assembly of preinitiation complex (PIC) on core promoter, a DNA sequence of∼ 100 base …

INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …

INTRODUCTION The multisubunit Mediator binds RNA polymerase II (Pol II), transduces
regulatory signals from transcription factors to Pol II, facilitates preinitiation complex (PIC) …

RNA polymerase II–mediated eukaryotic transcription starts with the assembly of the
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …

Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

Transcription is enabled by RNA polymerase and general factors that allow its progress
through the transcription cycle by facilitating initiation, elongation and termination. The …

Deletions within genes coding for subunits of the transcription coactivator SAGA caused
strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In …

Most eukaryotic promoter regions are divergently transcribed. As the RNA polymerase II pre-
initiation complex (PIC) is intrinsically asymmetric and responsible for transcription in a …

Cellular RNA levels are the result of a juggling act between RNA transcription, processing,
and degradation. By tuning one or more of these parameters, cells can rapidly alter the …

Methylotrophic yeasts have been widely recognized as a promising host for production of
recombinant proteins and value-added chemicals. Promoters for controlled gene expression …