Regulation of cell adhesion and migration via microtubule cytoskeleton organization, cell polarity, and phosphoinositide signaling
The capacity for cancer cells to metastasize to distant organs depends on their ability to
execute the carefully choreographed processes of cell adhesion and migration. As most …
execute the carefully choreographed processes of cell adhesion and migration. As most …
[HTML][HTML] Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
M Podolak, S Holota, Y Deyak, K Dziduch… - Bioorganic …, 2023 - Elsevier
Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
The new microtubule-targeting agent SIX2G induces immunogenic cell death in multiple myeloma
Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl
[1, 2] oxazole class of compounds binding the colchicine site was synthesized as cis …
[1, 2] oxazole class of compounds binding the colchicine site was synthesized as cis …
Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway
J Song, SH Wang, CH Song, WX Zhang, JX Zhu… - European Journal of …, 2022 - Elsevier
Novel N-benzylarylamide saderivatives were designed and synthesized, and their
antiproliferative activities were explored. Some of 51 target compounds exhibited potent …
antiproliferative activities were explored. Some of 51 target compounds exhibited potent …
Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential …
AHH Ahmed, MFA Mohamed, RM Allam, A Nafady… - Bioorganic …, 2022 - Elsevier
Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …
TK216 targets microtubules in Ewing sarcoma cells
JM Povedano, V Li, KE Lake, X Bai, R Rallabandi… - Cell Chemical …, 2022 - cell.com
Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein
formed by the chromosomal translocation t (11; 22). The small molecule TK216 was …
formed by the chromosomal translocation t (11; 22). The small molecule TK216 was …
SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis
S Deng, S Banerjee, H Chen, S Pochampally, Y Wang… - Cancer letters, 2023 - Elsevier
Extensive preclinical studies have shown that colchicine-binding site inhibitors (CBSIs) are
promising drug candidates for cancer therapy. Although numerous CBSIs were generated …
promising drug candidates for cancer therapy. Although numerous CBSIs were generated …
Molecular Docking of Cryptoconcatones to α-Tubulin and Related Pironetin Analogues
G Vergoten, C Bailly - Plants, 2023 - mdpi.com
Cryptoconcatones AL represent a series of 12 dihydropyrone derivatives isolated from the
evergreen tree Cryptocarya concinna Hance, which is well distributed in southeast Asia. The …
evergreen tree Cryptocarya concinna Hance, which is well distributed in southeast Asia. The …
A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo
YR Li, FF Liu, WB Liu, YF Zhang, XY Tian, XJ Fu… - Biochemical …, 2022 - Elsevier
Given the essential role of Epigenetic regulation in many biological processes, targeted
epigenetic drugs have been gradually applied to the treatment of tumors. Histone …
epigenetic drugs have been gradually applied to the treatment of tumors. Histone …
Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy
X Liu, J Jin, Y Wu, B Du, L Zhang, D Lu, Y Liu… - European Journal of …, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract with high
morbidity and mortality. Our previous studies have demonstrated that indole-chalcone …
morbidity and mortality. Our previous studies have demonstrated that indole-chalcone …