Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with
unclear mechanism. In this study, we retrospectively investigated a cohort of COVID-19 …

Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …

Due to their multidirectional influence, adipocytokines are currently the subject of numerous
intensive studies. Significant impact applies to many processes, both physiological and …

It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs
and secrete in normal and in pathological conditions several molecules, called, respectively …

Retinopathy of prematurity (ROP) is a leading cause of preventable vision loss in preterm
infants. While appropriate screening is crucial for early identification and treatment of ROP …

Despite improvements in medical and surgical therapies, a significant portion of patients
with critical limb ischemia (CLI) are considered as “no option” for revascularization. In this …

The apelinergic pathway has been generating increasing interest in the past few years for its
potential as a therapeutic target in several conditions associated with the cardiovascular and …

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra pars compacta. Several brain–gut peptides are able to exert …