Leptin, a hormone produced by the adipose tissue, is present in the circulation in proportion
to the amount of body fat [2, 5, 13, 23, 26, 40, 42]. Administration of purified recombinant …

We assessed the effect of early-onset exercise as a means of preventing childhood obesity
using juvenile male rats selectively bred to develop diet-induced obesity (DIO) or to be diet …

It seems likely that the neuropeptide Y (NPY)-leptin axis is involved in the regulation of
energy expenditure in man. The purpose of this study was to observe the effect of a model of …

To evaluate the effect of exercise training on serum leptin levels 50 sedentary subjects with
type 2 diabetes were enrolled in either 6 weeks of aerobic exercise training with diet therapy …

Perivascular adipose tissue (PVAT) is no longer recognised as simply a structural support
for the vasculature, and we now know that PVAT releases vasoactive factors which modulate …

Adipose tissue inflammation plays a role in cardiovascular (CV) and metabolic diseases
associated with obesity, insulin resistance, and type 2 diabetes mellitus (T2DM). The …

Many of the small percentage of previously obese humans who successfully maintain weight
loss report high levels of physical activity, suggesting a role for exercise in the maintenance …

Four‐week‐old, Fischer–Brown Norway F1‐generation male rats were given access to
voluntary running wheels for 21 days, and then the wheels were locked for 5 (WL5), 10 …

The hypothalamic-pituitary thyroid (HPT) axis modulates energy homeostasis. Its activity
decreases in conditions of negative energy balance but the effects of chronic exercise on the …

Mch1r-deficient (Mch1r−/−) mice are hyperphagic, hyperactive, lean, and resistant to diet-
induced obesity. To examine whether the MCH1R is involved in regulating activity-based …